Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics

by Michelle E Watts, Chen Wu, Lee L Rubin
Published 2019-07-01

MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

by Chen Wu, Michelle E. Watts, Lee L. Rubin
Published 2019-01-01

GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

by Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin
Published 2021-09-01

Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology.

by Jolanta Idkowiak-Baldys, Uma Santhanam, Sean M Buchanan, Kathleen Lindahl Pfaff, Lee L Rubin, John Lyga
Published 2019-01-01

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

by Martin L. Tomov, Alison O’Neil, Hamdah S. Abbasi, Beth A. Cimini, Anne E. Carpenter, Lee L. Rubin, Mark Bathe
Published 2021-06-01

Systemic nature of spinal muscular atrophy revealed by studying insurance claims.

by Scott L Lipnick, Denis M Agniel, Rahul Aggarwal, Nina R Makhortova, Samuel G Finlayson, Alexandra Brocato, Nathan Palmer, Basil T Darras, Isaac Kohane, Lee L Rubin
Published 2019-01-01

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

by Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton
Published 2014-09-01

Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells

by Sean M. Buchanan, Feodor D. Price, Alessandra Castiglioni, Amanda Wagner Gee, Joel Schneider, Mark N. Matyas, Monica Hayhurst, Mohammadsharif Tabebordbar, Amy J. Wagers, Lee L. Rubin
Published 2020-10-01

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

by Melissa B. Walsh, Eva Janzen, Emily Wingrove, Seyyedmohsen Hosseinibarkooie, Natalia Rodriguez Muela, Lance Davidow, Maria Dimitriadi, Erika M. Norabuena, Lee L. Rubin, Brunhilde Wirth, Anne C. Hart
Published 2020-09-01

CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

by Yassemi Koutmani, Ioannis A. Gampierakis, Alexia Polissidis, Methodios Ximerakis, Paraskevi N. Koutsoudaki, Alexandros Polyzos, George Agrogiannis, Sevasti Karaliota, Dimitra Thomaidou, Lee L. Rubin, Panagiotis K. Politis, Katia P. Karalis
Published 2019-10-01

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System

by Alessandra Rigamonti, Giuliana G. Repetti, Chicheng Sun, Feodor D. Price, Danielle C. Reny, Francesca Rapino, Karen Weisinger, Chen Benkler, Quinn P. Peterson, Lance S. Davidow, Emil M. Hansson, Lee L. Rubin
Published 2016-06-01

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

by Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Chris D. Hinojosa, William Tien-Street, Elias S. Manolakos, Kostas Vekrellis, Geraldine A. Hamilton, Lorna Ewart, Lee L. Rubin, Katia Karalis
Published 2021-10-01

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

by Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Grass, Gustavo M. Parfitt, Joao A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin
Published 2020-01-01

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

by Pratibha Tripathi, Natalia Rodriguez-Muela, Joseph R. Klim, A. Sophie de Boer, Sahil Agrawal, Jackson Sandoe, Claudia S. Lopes, Karolyn Sassi Ogliari, Luis A. Williams, Matthew Shear, Lee L. Rubin, Kevin Eggan, Qiao Zhou
Published 2017-08-01

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

by Natalia Rodriguez-Muela, Nadia K. Litterman, Erika M. Norabuena, Jesse L. Mull, Maria José Galazo, Chicheng Sun, Shi-Yan Ng, Nina R. Makhortova, Andrew White, Maureen M. Lynes, Wendy K. Chung, Lance S. Davidow, Jeffrey D. Macklis, Lee L. Rubin
Published 2017-02-01

Accelerating diagnosis of Parkinson’s disease through risk prediction

by William Yuan, Brett Beaulieu-Jones, Richard Krolewski, Nathan Palmer, Christine Veyrat-Follet, Francesca Frau, Caroline Cohen, Sylvie Bozzi, Meaghan Cogswell, Dinesh Kumar, Catherine Coulouvrat, Bruno Leroy, Tanya Z. Fischer, S. Pablo Sardi, Karen J. Chandross, Lee L. Rubin, Anne-Marie Wills, Isaac Kohane, Scott L. Lipnick
Published 2021-05-01

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

by Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, Madeline A. Lancaster, Frederick J. Livesey, Michael J. McConnell, Ronald D. McKay, Eric M. Morrow, Alysson R. Muotri, David M. Panchision, Lee L. Rubin, Akira Sawa, Frank Soldner, Hongjun Song, Lorenz Studer, Sally Temple, Flora M. Vaccarino, Jun Wu, Pierre Vanderhaeghen, Fred H. Gage, Rudolf Jaenisch
Published 2015-12-01