Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

by Juan C. Cedrón, Ángel G. Ravelo, Leticia G. León, José M. Padrón, Ana Estévez-Braun
Published 2015-07-01

Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells.

by Christopher J Stairiker, Marjan van Meurs, Leticia G Leon, A A Brouwers-Haspels, Laurine Rijsbergen, Yvonne M Mueller, Peter D Katsikis
Published 2020-01-01

Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation

by Rocco Sciarrillo, Anna Wojtuszkiewicz, Irsan E. Kooi, Leticia G. Leon, Edwin Sonneveld, Roland P. Kuiper, Gerrit Jansen, Elisa Giovannetti, Gertjan J.L. Kaspers, Jacqueline Cloos
Published 2020-03-01

Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG.

by Ogan K Kumova, Adam J Fike, Jillian L Thayer, Linda T Nguyen, Joshua Chang Mell, Judy Pascasio, Christopher Stairiker, Leticia G Leon, Peter D Katsikis, Alison J Carey
Published 2019-10-01

Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

by Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters
Published 2013-01-01

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

by Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti
Published 2017-01-01

High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer.

by Elisa Giovannetti, Arjan van der Velde, Niccola Funel, Enrico Vasile, Vittorio Perrone, Leticia G Leon, Nelide De Lio, Amir Avan, Sara Caponi, Luca E Pollina, Valentina Gallá, Hiroko Sudo, Alfredo Falcone, Daniela Campani, Ugo Boggi, Godefridus J Peters
Published 2012-01-01

Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.

by Jin-Hyeok Hwang, Johannes Voortman, Elisa Giovannetti, Seth M Steinberg, Leticia G Leon, Yong-Tae Kim, Niccola Funel, Joo Kyung Park, Min A Kim, Gyeong Hoon Kang, Sun-Whe Kim, Marco Del Chiaro, Godefridus J Peters, Giuseppe Giaccone
Published 2010-05-01

Fatigue in Sjögren's Syndrome: A Search for Biomarkers and Treatment Targets

by Iris L. A. Bodewes, Peter J. van der Spek, Peter J. van der Spek, Leticia G. Leon, Annemarie J. M. Wijkhuijs, Cornelia G. van Helden-Meeuwsen, Liselotte Tas, Marco W. J. Schreurs, Paul L. A. van Daele, Peter D. Katsikis, Marjan A. Versnel
Published 2019-02-01

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.

by Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Published 2020-06-01

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

by Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom
Published 2018-06-01