Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies

by Godefridus J. Peters
Published 2015-11-01

ADME/DMPK in the development and use of tyrosine and serine-threonine kinase inhibitors

by Godefridus J. Peters, Kin Tam
Published 2016-10-01

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro

by Godefridus J. Peters, Godefridus J. Peters, Frank P. A. van Gemert, Ietje Kathmann, Guru Reddy, Saskia A. G. M. Cillessen, Gerrit Jansen
Published 2020-10-01

Tissue distribution of crizotinib and gemcitabine combination in a patient-derived orthotopic mouse model of pancreatic cancer

by Richard J. Honeywell, Amir Avan, Elisa Giovannetti, Godefridus J. Peters
Published 2016-12-01

Transport of six tyrosine kinase inhibitors: active or passive?

by Richard J. Honeywell, Sarina Hitzerd, Ietje Kathmann, Godefridus J. Peters
Published 2016-03-01

Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance

by Daniel J. de Klerk, Richard J. Honeywell, Gerrit Jansen, Godefridus J. Peters
Published 2018-12-01

The role of pharmacology in anticancer drug development

by Godefridus J. Peters, Anne-Sophie Govaerts, Hans R. Hendriks, for EORTC Pharmacology and Molecular Mechanism Group
Published 2018-03-01

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

by Paul Noordhuis, Adrianus C. Laan, Kasper van de Born, Richard J. Honeywell, Godefridus J. Peters
Published 2019-07-01

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models

by Pei Pei Che, Alessandro Gregori, Omidreza Firuzi, Max Dahele, Peter Sminia, Godefridus J. Peters, Elisa Giovannetti
Published 2020-08-01

Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC)

by Rosa Wijnen, Camilla Pecoraro, Daniela Carbone, Hamid Fiuji, Amir Avan, Godefridus J. Peters, Elisa Giovannetti, Patrizia Diana
Published 2021-08-01

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

by Barbara Frigerio, Claudia Bizzoni, Gerrit Jansen, Christopher P. Leamon, Godefridus J. Peters, Philip S. Low, Larry H. Matherly, Mariangela Figini
Published 2019-03-01

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

by Richard J. Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F. Smit, Maria N. Rovithi, Henk M.W. Verheul, Godefridus J. Peters
Published 2020-11-01

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the...

by Dzjemma Sarkisjan, Joris R. Julsing, Btissame El Hassouni, Richard J. Honeywell, Ietje Kathmann, Larry H. Matherly, Young B. Lee, Deog J. Kim, Godefridus J. Peters
Published 2020-04-01

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

by Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters
Published 2016-01-01

“Open Sesame?”: Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity in the Uptake and Cytotoxicity...

by Ornella Randazzo, Filippo Papini, Giulia Mantini, Alessandro Gregori, Barbara Parrino, Daniel S. K. Liu, Stella Cascioferro, Daniela Carbone, Godefridus J. Peters, Adam E. Frampton, Ingrid Garajova, Elisa Giovannetti
Published 2020-10-01

Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

by Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters
Published 2013-01-01

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.

by Sanne R Martens-de Kemp, Simone U Dalm, Fiona M J Wijnolts, Arjen Brink, Richard J Honeywell, Godefridus J Peters, Boudewijn J M Braakhuis, Ruud H Brakenhoff
Published 2013-01-01

AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients.

by Abolfazl Avan, Amir Avan, Tessa Y S Le Large, Andrea Mambrini, Niccola Funel, Mina Maftouh, Majid Ghayour-Mobarhan, Maurizio Cantore, Ugo Boggi, Godefridus J Peters, Paola Pacetti, Elisa Giovannetti
Published 2014-01-01

Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography.

by Virginie Frings, Astrid A M van der Veldt, Ronald Boellaard, Gerarda J M Herder, Elisa Giovannetti, Richard Honeywell, Godefridus J Peters, Erik Thunnissen, Otto S Hoekstra, Egbert F Smit
Published 2013-01-01

3-(6-Phenylimidazo [2,1-<i>b</i>][1,3,4]thiadiazol-2-yl)-1<i>H</i>-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

by Stella Cascioferro, Giovanna Li Petri, Barbara Parrino, Btissame El Hassouni, Daniela Carbone, Vincenzo Arizza, Ugo Perricone, Alessandro Padova, Niccola Funel, Godefridus J. Peters, Girolamo Cirrincione, Elisa Giovannetti, Patrizia Diana
Published 2020-01-01