Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in p...

by Lutz Frölich, Glen Wunderlich, Claus Thamer, Michael Roehrle, Miguel Garcia, Bruno Dubois
Published 2019-02-01

Promoting neuroplasticity and neuropsychological functioning in frailty through an app-based sensorimotor training: study protocol for a randomized trial

by Florian Beier, Martin Löffler, Frauke Nees, Lucrezia Hausner, Lutz Frölich, Herta Flor
Published 2021-06-01

Case report: a giant arachnoid cyst masking Alzheimer’s disease

by Anna-Sophia Wahl, Martin Löffler, Lucrezia Hausner, Michaela Ruttorf, Frauke Nees, Lutz Frölich
Published 2019-09-01

Tablet-based sensorimotor home-training system for amnestic mild cognitive impairments in the elderly: design of a randomised clinical trial

by Robin Bekrater-Bodmann, Annette Löffler, Stefano Silvoni, Lutz Frölich, Simon Desch, Dieter Kleinböhl, Herta Flor
Published 2019-08-01

Insights into globalization: comparison of patient characteristics and disease progression among geographic regions in a multinational Alzheimer’s disease clinical program

by Jeffrey L. Cummings, Alireza Atri, Clive Ballard, Neli Boneva, Lutz Frölich, José Luis Molinuevo, Lars Lau Raket, Pierre N. Tariot
Published 2018-11-01

On the path to 2025: understanding the Alzheimer’s disease continuum

by Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois
Published 2017-08-01

Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

by Shahzad Ahmad, Adelina Orellana, Isabelle Kohler, Lutz Frölich, Itziar de Rojas, Silvia Gil, Mercè Boada, Isabel Hernández, Lucrezia Hausner, Margot H. M. Bakker, Alfredo Cabrera-Socorro, Najaf Amin, Alfredo Ramírez, Agustín Ruiz, Thomas Hankemeier, Cornelia M. Van Duijn
Published 2020-10-01

Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment.

by Steffen Wolfsgruber, Michael Wagner, Klaus Schmidtke, Lutz Frölich, Alexander Kurz, Stefanie Schulz, Harald Hampel, Isabella Heuser, Oliver Peters, Friedel M Reischies, Holger Jahn, Christian Luckhaus, Michael Hüll, Hermann-Josef Gertz, Johannes Schröder, Johannes Pantel, Otto Rienhoff, Eckart Rüther, Fritz Henn, Jens Wiltfang, Wolfgang Maier, Johannes Kornhuber, Frank Jessen
Published 2014-01-01

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

by Elles Konijnenberg, Betty M. Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E. Teunissen, Robert Veerhuis, August B. Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visser
Published 2020-05-01

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

by Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff, Stefanie Wolf, Chris Bauer, Johannes Schuchhardt, Isabella Heuser, Eckart Rüther, Fritz Henn, Wolfgang Maier, Jens Wiltfang, Johannes Kornhuber
Published 2017-10-01

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.

by Emily Baker, Rebecca Sims, Ganna Leonenko, Aura Frizzati, Janet C Harwood, Detelina Grozeva, GERAD/PERADES, CHARGE, ADGC, EADI, IGAP consortia, Kevin Morgan, Peter Passmore, Clive Holmes, John Powell, Carol Brayne, Michael Gill, Simon Mead, Paola Bossù, Gianfranco Spalletta, Alison M Goate, Carlos Cruchaga, Wolfgang Maier, Reinhard Heun, Frank Jessen, Oliver Peters, Martin Dichgans, Lutz FröLich, Alfredo Ramirez, Lesley Jones, John Hardy, Dobril Ivanov, Matthew Hill, Peter Holmans, Nicholas D Allen, B Paul Morgan, Sudha Seshadri, Gerard D Schellenberg, Philippe Amouyel, Julie Williams, Valentina Escott-Price
Published 2019-01-01

Consensus guidelines for lumbar puncture in patients with neurological diseases

by Sebastiaan Engelborghs, Ellis Niemantsverdriet, Hanne Struyfs, Kaj Blennow, Raf Brouns, Manuel Comabella, Irena Dujmovic, Wiesje van derFlier, Lutz Frölich, Daniela Galimberti, Sharmilee Gnanapavan, Bernhard Hemmer, Erik Hoff, Jakub Hort, Ellen Iacobaeus, Martin Ingelsson, Frank Jan de Jong, Michael Jonsson, Michael Khalil, Jens Kuhle, Alberto Lleó, Alexandre deMendonça, José Luis Molinuevo, Guy Nagels, Claire Paquet, Lucilla Parnetti, Gerwin Roks, Pedro Rosa‐Neto, Philip Scheltens, Constance Skårsgard, Erik Stomrud, Hayrettin Tumani, Pieter Jelle Visser, Anders Wallin, Bengt Winblad, Henrik Zetterberg, Flora Duits, Charlotte E. Teunissen
Published 2017-01-01

Exploring Genetic Associations of Alzheimer’s Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes

by Ana Espinosa, Begoña Hernández-Olasagarre, Sonia Moreno-Grau, Luca Kleineidam, Luca Kleineidam, Luca Kleineidam, Stefanie Heilmann-Heimbach, Stefanie Heilmann-Heimbach, Isabel Hernández, Steffen Wolfsgruber, Steffen Wolfsgruber, Holger Wagner, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Octavio Rodríguez-Gómez, Carla Abdelnour, Silvia Gil, Marta Marquié, Miguel A. Santos-Santos, Ángela Sanabria, Gemma Ortega, Gemma Monté-Rubio, Alba Pérez, Marta Ibarria, Susana Ruiz, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Michael Hüll, Jens Wiltfang, Tobias Luck, Steffi Riedel-Heller, Laura Montrreal, Pilar Cañabate, Mariola Moreno, Silvia Preckler, Nuria Aguilera, Itziar de Rojas, Adelina Orellana, Montserrat Alegret, Sergi Valero, Markus M. Nöthen, Markus M. Nöthen, Michael Wagner, Michael Wagner, Frank Jessen, Frank Jessen, Frank Jessen, Lluis Tárraga, Mercè Boada, Alfredo Ramírez, Alfredo Ramírez, Agustín Ruiz
Published 2018-10-01

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

by Lesley Jones, Peter A Holmans, Marian L Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Reinhard Heun, Heike Kölsch, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Eckhard Rüther, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, John Hardy, Michael C O'Donovan, Michael J Owen, Julie Williams
Published 2010-11-01

Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

by Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams
Published 2011-01-01

Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease.

by Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams
Published 2011-01-01