Macrophage as a Peripheral Pain Regulator

by Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
Published 2021-07-01

Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice

by Kazuki Matsui, Yuka Terada, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata
Published 2020-05-01

Colonic Hydrogen Sulfide–Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Cav3.2 and TRPA1 Channels in Mice

by Maho Tsubota-Matsunami, Yumi Noguchi, Yasumasa Okawa, Fumiko Sekiguchi, Atsufumi Kawabata
Published 2012-01-01

Selective sensitization of C-fiber nociceptors by hydrogen sulfide

by Yuka Aoki, Maho Tsubota, Yuta Nishimoto, Yumi Maeda, Fumiko Sekiguchi, Atsufumi Kawabata
Published 2016-01-01

Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain

by Yuka Terada, Mayuko Fujimura, Sachiyo Nishimura, Maho Tsubota, Fumiko Sekiguchi, Hiroyuki Nishikawa, Atsufumi Kawabata
Published 2013-01-01

Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels

by Maho Tsubota, Tomoka Ozaki, Yuko Hayashi, Yasumasa Okawa, Ayaka Fujimura, Fumiko Sekiguchi, Hiroyuki Nishikawa, Atsufumi Kawabata
Published 2018-01-01

NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

by Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata
Published 2019-06-01

Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide–Receptor Activation in Rats With Spinal Nerve Injury–Induced Neuropathy

by Tomoko Takahashi, Kazumasa Okubo, Shota Kojima, Hiroyuki Nishikawa, Motohide Takemura, Maho Tsubota-Matsunami, Fumiko Sekiguchi, Atsufumi Kawabata
Published 2013-01-01

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

by Masahiro Murakami-Nakayama, Maho Tsubota, Saki Hiruma, Fumiko Sekiguchi, Kenji Matsuyama, Takeshi Kimura, Masahiro Moriyama, Atsufumi Kawabata
Published 2015-02-01

HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model

by Yuhei Irie, Maho Tsubota, Mariko Maeda, Shiori Hiramoto, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
Published 2020-06-01

Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study

by Tomoyoshi Miyamoto, Shiori Hiramoto, Ayano Kanto, Maho Tsubota, Masanori Fujitani, Hiroki Fukuyama, Shigekatsu Hatanaka, Fumiko Sekiguchi, Yuichi Koizumi, Atsufumi Kawabata
Published 2021-05-01

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

by Daichi Yamasoba, Maho Tsubota, Risa Domoto, Fumiko Sekiguchi, Hiroyuki Nishikawa, Keyue Liu, Masahiro Nishibori, Hiroyasu Ishikura, Tetsushi Yamamoto, Atsushi Taga, Atsufumi Kawabata
Published 2016-02-01

Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of antic...

by Maho Tsubota, Ryotaro Fukuda, Yusuke Hayashi, Takaya Miyazaki, Shin Ueda, Rika Yamashita, Nene Koike, Fumiko Sekiguchi, Hidenori Wake, Shuji Wakatsuki, Yuka Ujiie, Toshiyuki Araki, Masahiro Nishibori, Atsufumi Kawabata
Published 2019-10-01

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice

by Kazuki Matsui, Maho Tsubota, Saaya Fukushi, Nene Koike, Hiroshi Masuda, Yoshihito Kasanami, Takaya Miyazaki, Fumiko Sekiguchi, Tsuyako Ohkubo, Shigeru Yoshida, Yutaro Mukai, Akira Oita, Mitsutaka Takada, Atsufumi Kawabata
Published 2019-07-01

Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H₂S/Ca_v3.2 Signaling in Mice

by Shiori Hiramoto, Maho Tsubota, Kaoru Yamaguchi, Kyoko Okazaki, Aya Sakaegi, Yuki Toriyama, Junichi Tanaka, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Huy Du Nguyen, Takuya Okada, Naoki Toyooka, Atsufumi Kawabata
Published 2020-07-01