Regulators of Homologous Recombination Repair as Novel Targets for Cancer Treatment

by Małgorzata ekrajewska, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Marcel A.T.M. Van Vugt
Published 2015-03-01

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer c...

by Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. vanVugt
Published 2019-11-01

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

by Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Published 2019-01-01

Transcriptional effects of copy number alterations in a large set of human cancers

by Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published 2020-02-01

miR-371a-3p, miR-373-3p and miR-367-3p as Serum Biomarkers in Metastatic Testicular Germ Cell Cancers Before, During and After Chemotherapy

by Ximena Rosas Plaza, Ton van Agthoven, Coby Meijer, Marcel A. T. M. van Vugt, Steven de Jong, Jourik A. Gietema, Leendert H. J. Looijenga
Published 2019-10-01

Improving gene function predictions using independent transcriptional components

by Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Published 2021-03-01

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

by Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt
Published 2019-08-01

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

by Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Published 2019-07-01

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

by Renske van Leuken, Linda Clijsters, Wouter van Zon, Dan Lim, XueBiao Yao, Rob M F Wolthuis, Michael B Yaffe, René H Medema, Marcel A T M van Vugt
Published 2009-01-01

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

by Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Published 2017-07-01

Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy

by Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast
Published 2021-08-01

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.

by Alina Fedoseienko, Hylke W Wieringa, G Bea A Wisman, Evelien Duiker, Anna K L Reyners, Marten H Hofker, Ate G J van der Zee, Bart van de Sluis, Marcel A T M van Vugt
Published 2016-01-01

A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

by Thijs T. Wind, Mathilde Jalving, Jacco J. de Haan, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Dirk-Jan Reijngoud, Rozemarijn S. van Rijn, John B. A. G. Haanen, Christian U. Blank, Geke A. P. Hospers, Rudolf S. N. Fehrmann
Published 2019-03-01

Comparison of Carboplatin With 5-Fluorouracil vs. Cisplatin as Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

by Saskia H. Hanemaaijer, Iris C. Kok, Rudolf S. N. Fehrmann, Bert van der Vegt, Jourik A. Gietema, Boudewijn E. C. Plaat, Marcel A. T. M. van Vugt, Marije R. Vergeer, C. René Leemans, Johannes A. Langendijk, Jens Voortman, Jan Buter, Sjoukje F. Oosting
Published 2020-06-01

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

by Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe
Published 2010-01-01

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

by Walderik W. Zomerman, Sabine L.A. Plasschaert, Siobhan Conroy, Frank J. Scherpen, Tiny G.J. Meeuwsen-de Boer, Harm J. Lourens, Sergi Guerrero Llobet, Marlinde J. Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E.M. Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C. van Kempen, Anke van den Berg, Daniël O. Warmerdam, Frank A.E. Kruyt, Floris Foijer, Marcel A.T.M. van Vugt, Wilfred F.A. den Dunnen, Eelco W. Hoving, Victor Guryev, Eveline S.J.M. de Bont, Sophia W.M. Bruggeman
Published 2018-03-01