Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

by Roxanne P. Smith, Jason J. Paxman, Martin J. Scanlon, Begoña Heras
Published 2016-07-01

The Fragment-Based Development of a Benzofuran Hit as a New Class of <i>Escherichia coli</i> DsbA Inhibitors

by Luke F. Duncan, Geqing Wang, Olga V. Ilyichova, Martin J. Scanlon, Begoña Heras, Belinda M. Abbott
Published 2019-10-01

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

by Zorik Chilingaryan, Stephen J. Headey, Allen T. Y. Lo, Zhi-Qiang Xu, Gottfried Otting, Nicholas E. Dixon, Martin J. Scanlon, Aaron J. Oakley
Published 2018-02-01

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide.

by Geqing Wang, Christopher A MacRaild, Biswaranjan Mohanty, Mehdi Mobli, Nathan P Cowieson, Robin F Anders, Jamie S Simpson, Sheena McGowan, Raymond S Norton, Martin J Scanlon
Published 2014-01-01

Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes.

by Fabian Kurth, Kieran Rimmer, Lakshmanane Premkumar, Biswaranjan Mohanty, Wilko Duprez, Maria A Halili, Stephen R Shouldice, Begoña Heras, David P Fairlie, Martin J Scanlon, Jennifer L Martin
Published 2013-01-01

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.

by Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
Published 2017-01-01

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

by Susannah Piek, Zhirui Wang, Jhuma Ganguly, Adam M Lakey, Stephanie N Bartley, Shakeel Mowlaboccus, Anandhi Anandan, Keith A Stubbs, Martin J Scanlon, Alice Vrielink, Parastoo Azadi, Russell W Carlson, Charlene M Kahler
Published 2014-01-01