Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

by Marzia Perluigi, D. Allan Butterfield
Published 2012-01-01

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

by Marzia Perluigi, Fabio Di Domenico, D. Allan Butterfield
Published 2015-12-01

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

by Marzia Perluigi, Antonella Tramutola, Sara Pagnotta, Eugenio Barone, D. Allan Butterfield
Published 2020-08-01

It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease

by Antonella Tramutola, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi, D. Allan Butterfield
Published 2016-01-01

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

by Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Elizabeth Head, D. Allan Butterfield, Marzia Perluigi, Eugenio Barone
Published 2020-04-01

Poly-ubiquitin profile in Alzheimer disease brain

by Antonella Tramutola, Francesca Triani, Fabio Di Domenico, Eugenio Barone, Jian Cai, Jon B. Klein, Marzia Perluigi, D. Allan Butterfield
Published 2018-10-01

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

by Chiara Lanzillotta, Ilaria Zuliani, Chirag Vasavda, Solomon H. Snyder, Bindu D. Paul, Marzia Perluigi, Fabio Di Di Domenico, Eugenio Barone
Published 2020-07-01

Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions

by Mara Dierssen, Mara Dierssen, Mara Dierssen, Mara Dierssen, Marta Fructuoso, María Martínez de Lagrán, María Martínez de Lagrán, Marzia Perluigi, Eugenio Barone
Published 2020-07-01

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

by Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi, Fabio Di Domenico
Published 2018-11-01

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

by Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Published 2019-05-01

Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics ana...

by Ada Fiorini, Tatiana Koudriavtseva, Elona Bucaj, Raffaella Coccia, Cesira Foppoli, Alessandra Giorgi, M Eugenia Schininà, Fabio Di Domenico, Federico De Marco, Marzia Perluigi
Published 2013-01-01

Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53.

by Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B Klein, Daret St Clair, D Allan Butterfield
Published 2012-01-01

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression...

by Tanea Reed, Marzia Perluigi, Rukhsana Sultana, William M. Pierce, Jon B. Klein, Delano M. Turner, Raffaella Coccia, William R. Markesbery, D. Allan Butterfield
Published 2008-04-01

Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children

by Chiara Lanzillotta, Viviana Greco, Diletta Valentini, Alberto Villani, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Sara Pagnotta, Eugenio Barone, Andrea Urbani, Fabio Di Domenico, Marzia Perluigi
Published 2020-11-01

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome

by Ilaria Zuliani, Chiara Urbinati, Daniela Valenti, Maria Cristina Quattrini, Vanessa Medici, Livia Cosentino, Donatella Pietraforte, Fabio Di Domenico, Marzia Perluigi, Rosa Anna Vacca, Bianca De Filippis
Published 2020-06-01

Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer’s Disease Progression

by Virginia Protto, Antonella Tramutola, Marco Fabiani, Maria Elena Marcocci, Giorgia Napoletani, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Marzia Perluigi, Fabio Di Domenico, Giovanna De Chiara, Anna Teresa Palamara
Published 2020-06-01

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

by Fabio Di Domenico, Antonella Tramutola, Eugenio Barone, Chiara Lanzillotta, Olivia Defever, Andrea Arena, Ilaria Zuliani, Cesira Foppoli, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, D. Allan Butterfield, Marzia Perluigi
Published 2019-05-01

Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues.

by Federico De Marco, Elona Bucaj, Cesira Foppoli, Ada Fiorini, Carla Blarzino, Kozeta Filipi, Alessandra Giorgi, Maria Eugenia Schininà, Fabio Di Domenico, Raffaella Coccia, D Allan Butterfield, Marzia Perluigi
Published 2012-01-01

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

by Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Eugenio Barone, Marzia Perluigi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Francesco Bellanti, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi, Fabio Di Domenico
Published 2021-04-01

Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression

by Antonella Tramutola, Susanna Falcucci, Umberto Brocco, Francesca Triani, Chiara Lanzillotta, Michele Donati, Chiara Panetta, Fabiola Luzi, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Marzia Perluigi, Fabio Di Domenico, Federico De Marco
Published 2020-01-01