“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus

by Darya Belikova, Angelika Jochim, Jeffrey Power, Matthew T. G. Holden, Simon Heilbronner
Published 2020-07-01

The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression

by Claire E. Turner, Matthew T. G. Holden, Beth Blane, Carolyne Horner, Sharon J. Peacock, Shiranee Sriskandan
Published 2019-12-01

The impact of recombination on dN/dS within recently emerged bacterial clones.

by Santiago Castillo-Ramírez, Simon R Harris, Matthew T G Holden, Miao He, Julian Parkhill, Stephen D Bentley, Edward J Feil
Published 2011-07-01

Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice

by Catriona P. Harkins, Bruno Pichon, Michel Doumith, Julian Parkhill, Henrik Westh, Alexander Tomasz, Herminia de Lencastre, Stephen D. Bentley, Angela M. Kearns, Matthew T. G. Holden
Published 2017-07-01

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes

by Marta Zapotoczna, Gustavo P. Riboldi, Ahmed M. Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A. Morrissey, Paul J. Planet, Matthew T. G. Holden, Kevin J. Waldron, Joan A. Geoghegan
Published 2018-10-01

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243.

by Andrea J Dowling, Paul A Wilkinson, Matthew T G Holden, Michael A Quail, Stephen D Bentley, Julia Reger, Nicholas R Waterfield, Richard W Titball, Richard H Ffrench-Constant
Published 2010-12-01

SpeS: A Novel Superantigen and Its Potential as a Vaccine Adjuvant against Strangles

by C. Coral Dominguez-Medina, Nicola L. Rash, Sylvain Robillard, Carl Robinson, Androulla Efstratiou, Karen Broughton, Julian Parkhill, Matthew T.G. Holden, Maria R. Lopez-Alvarez, Romain Paillot, Andrew S. Waller
Published 2020-06-01

Superantigenic activity of emm3 Streptococcus pyogenes is abrogated by a conserved, naturally occurring smeZ mutation.

by Claire E Turner, Mary Sommerlad, Karen McGregor, Frances J Davies, Bruno Pichon, Deborah L W Chong, Leili Farzaneh, Matthew T G Holden, Brian G Spratt, Androulla Efstratiou, Shiranee Sriskandan
Published 2012-01-01

ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae

by Janine T Bosse, Yanwen Li, Roberto Fernandez Crespo, Roy R Chaudhuri, Jon Rogers, Matthew T G Holden, Duncan Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford
Published 2016-06-01

Routine use of microbial whole genome sequencing in diagnostic and public health microbiology.

by Claudio U Köser, Matthew J Ellington, Edward J P Cartwright, Stephen H Gillespie, Nicholas M Brown, Mark Farrington, Matthew T G Holden, Gordon Dougan, Stephen D Bentley, Julian Parkhill, Sharon J Peacock
Published 2012-01-01

Global Scale Dissemination of ST93: A Divergent Staphylococcus aureus Epidemic Lineage That Has Recently Emerged From Remote Northern Australia

by Sebastiaan J. van Hal, Eike J. Steinig, Eike J. Steinig, Patiyan Andersson, Matthew T. G. Holden, Matthew T. G. Holden, Simon R. Harris, Graeme R. Nimmo, Deborah A. Williamson, Helen Heffernan, S. R. Ritchie, Angela M. Kearns, Matthew J. Ellington, Elizabeth Dickson, Herminia de Lencastre, Herminia de Lencastre, Geoffrey W. Coombs, Geoffrey W. Coombs, Stephen D. Bentley, Julian Parkhill, Deborah C. Holt, Phillip M. Giffard, Steven Y. C. Tong, Steven Y. C. Tong
Published 2018-07-01

Dispensing Antibiotics without Prescription at Community Pharmacies and Accredited Drug Dispensing Outlets in Tanzania: A Cross-Sectional Study

by Pendo M. Ndaki, Martha F. Mushi, Joseph R. Mwanga, Eveline T. Konje, Nyanda E. Ntinginya, Blandina T. Mmbaga, Katherine Keenan, Wilber Sabiiti, Mike Kesby, Fernando Benitez-Paez, Alison Sandeman, Matthew T. G. Holden, Stephen E. Mshana, HATUA Consortium
Published 2021-08-01

Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases

by Sigríður Bjornsdíóttir, Simon R. Harris, Vilhjíóálmur Svansson, Eggert Gunnarsson, íóáÓlof G. SigurðardíóáÓóttir, Kristina Gammeljord, Karen F. Steward, J. Richard Newton, Carl Robinson, Amelia R. L. Charbonneau, Julian Parkhill, Matthew T. G. Holden, Andrew S. Waller, Mark J. Walker, Gary M. Dunny
Published 2017-08-01

Whole genome investigation of a divergent clade of the pathogen Streptococcus suis

by Abiyad eBaig, Lucy A Weinert, Sarah E Peters, Kate J Howell, Roy R Chaudhuri, Jinhong eWang, Matthew T.G. Holden, Julian eParkhill, Paul eLangford, Andrew eRycroft, Brendan W Wren, Alexander W Tucker, Duncan J Maskell
Published 2015-11-01

A single multilocus sequence typing (MLST) scheme for seven pathogenic Leptospira species.

by Siriphan Boonsilp, Janjira Thaipadungpanit, Premjit Amornchai, Vanaporn Wuthiekanun, Mark S Bailey, Matthew T G Holden, Cuicai Zhang, Xiugao Jiang, Nobuo Koizumi, Kyle Taylor, Renee Galloway, Alex R Hoffmaster, Scott Craig, Lee D Smythe, Rudy A Hartskeerl, Nicholas P Day, Narisara Chantratita, Edward J Feil, David M Aanensen, Brian G Spratt, Sharon J Peacock
Published 2013-01-01

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.

by Nicholas R Thomson, Sarah Howard, Brendan W Wren, Matthew T G Holden, Lisa Crossman, Gregory L Challis, Carol Churcher, Karen Mungall, Karen Brooks, Tracey Chillingworth, Theresa Feltwell, Zahra Abdellah, Heidi Hauser, Kay Jagels, Mark Maddison, Sharon Moule, Mandy Sanders, Sally Whitehead, Michael A Quail, Gordon Dougan, Julian Parkhill, Michael B Prentice
Published 2006-12-01

Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States.

by Naglaa Mohamed, Yekaterina Timofeyeva, Dorota Jamrozy, Eduardo Rojas, Li Hao, Natalie C Silmon de Monerri, Julio Hawkins, Guy Singh, Bing Cai, Paul Liberator, Shite Sebastian, Robert G K Donald, Ingrid L Scully, C Hal Jones, C Buddy Creech, Isaac Thomsen, Julian Parkhill, Sharon J Peacock, Kathrin U Jansen, Matthew T G Holden, Annaliesa S Anderson
Published 2019-01-01

Protocol for an interdisciplinary cross-sectional study investigating the social, biological and community-level drivers of antimicrobial resistance (AMR): Holistic Approach to Unr...

by Andy G Lynch, Joel Bazira, Derek J Sloan, Catherine Kansiime, Stella Neema, Wilber Sabiiti, Stephen H Gillespie, David M Aanensen, John Stelling, Alison Elliott, Benon B Asiimwe, John Kiiru, Stephen E Mshana, Katherine Keenan, Mike Kesby, Joseph R Mwanga, V Anne Smith, Alison Sandeman, Gibson E Kibiki, Matthew T G Holden, Martha F Mushi, Arun Gonzales Decano, Dominique L Green, John Mwaniki, Nyanda E Ntinginya
Published 2021-03-01

Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens.

by Matthew T G Holden, Zoe Heather, Romain Paillot, Karen F Steward, Katy Webb, Fern Ainslie, Thibaud Jourdan, Nathalie C Bason, Nancy E Holroyd, Karen Mungall, Michael A Quail, Mandy Sanders, Mark Simmonds, David Willey, Karen Brooks, David M Aanensen, Brian G Spratt, Keith A Jolley, Martin C J Maiden, Michael Kehoe, Neil Chanter, Stephen D Bentley, Carl Robinson, Duncan J Maskell, Julian Parkhill, Andrew S Waller
Published 2009-03-01

Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines

by Silvia Argimón, Melissa A. L. Masim, June M. Gayeta, Marietta L. Lagrada, Polle K. V. Macaranas, Victoria Cohen, Marilyn T. Limas, Holly O. Espiritu, Janziel C. Palarca, Jeremiah Chilam, Manuel C. Jamoralin, Alfred S. Villamin, Janice B. Borlasa, Agnettah M. Olorosa, Lara F. T. Hernandez, Karis D. Boehme, Benjamin Jeffrey, Khalil Abudahab, Charmian M. Hufano, Sonia B. Sia, John Stelling, Matthew T. G. Holden, David M. Aanensen, Celia C. Carlos
Published 2020-06-01