Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

by Dereje Abate Negatu, Yoshiyuki Yamada, Yu Xi, Mei Lin Go, Matthew Zimmerman, Uday Ganapathy, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Published 2019-03-01

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

by Landry Blanc, Isaac B Daudelin, Brendan K Podell, Pei-Yu Chen, Matthew Zimmerman, Amanda J Martinot, Rada M Savic, Brendan Prideaux, Véronique Dartois
Published 2018-11-01

Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis

by Pallavi Chandra, Li He, Matthew Zimmerman, Guozhe Yang, Stefan Köster, Mireille Ouimet, Han Wang, Kathyrn J. Moore, Véronique Dartois, Joel D. Schilling, Jennifer A. Philips
Published 2020-07-01

Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization.

by Natasha Strydom, Sneha V Gupta, William S Fox, Laura E Via, Hyeeun Bang, Myungsun Lee, Seokyong Eum, TaeSun Shim, Clifton E Barry, Matthew Zimmerman, Véronique Dartois, Radojka M Savic
Published 2019-04-01

Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.

by Sean Ekins, Peter B Madrid, Malabika Sarker, Shao-Gang Li, Nisha Mittal, Pradeep Kumar, Xin Wang, Thomas P Stratton, Matthew Zimmerman, Carolyn Talcott, Pauline Bourbon, Mike Travers, Maneesh Yadav, Joel S Freundlich
Published 2015-01-01

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

by Swarnava Chaudhuri, Liping Li, Matthew Zimmerman, Yuemeng Chen, Yu-Xiang Chen, Melody N Toosky, Michelle Gardner, Miaomiao Pan, Yang-Yang Li, Qingwen Kawaji, Jun-Hao Zhu, Hong-Wei Su, Amanda J Martinot, Eric J Rubin, Veronique Anne Dartois, Babak Javid
Published 2018-08-01

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB.

by Ruslana Bryk, Shashirekha Mundhra, Xiuju Jiang, Madeleine Wood, Daniel Pfau, Elaina Weber, Suna Park, Li Zhang, Colin Wilson, Renier Van der Westhuyzen, Leslie Street, Kelly Chibale, Matthew Zimmerman, Véronique Dartois, Nunzia Pastore, Andrea Ballabio, Natalie Hawryluk, Stacie Canan, Vikram Khetani, Joseph Camardo, Carl Nathan
Published 2020-06-01

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

by Tiago Beites, Kathryn O’Brien, Divya Tiwari, Curtis A. Engelhart, Shaun Walters, Jenna Andrews, Hee-Jeong Yang, Michelle L. Sutphen, Danielle M. Weiner, Emmanuel K. Dayao, Matthew Zimmerman, Brendan Prideaux, Prashant V. Desai, Thierry Masquelin, Laura E. Via, Véronique Dartois, Helena I. Boshoff, Clifton E. Barry, Sabine Ehrt, Dirk Schnappinger
Published 2019-10-01

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

by Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Published 2018-12-01