Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

by Davide Normanno, Aurélie Négrel, Abinadabe J de Melo, Stéphane Betzi, Katheryn Meek, Mauro Modesti
Published 2017-05-01

RADX Modulates RAD51 Activity to Control Replication Fork Protection

by Kamakoti P. Bhat, Archana Krishnamoorthy, Huzefa Dungrawala, Edwige B. Garcin, Mauro Modesti, David Cortez
Published 2018-07-01

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination

by Ineke Brouwer, Hongshan Zhang, Andrea Candelli, Davide Normanno, Erwin J.G. Peterman, Gijs J.L. Wuite, Mauro Modesti
Published 2017-03-01

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

by Satish K. Tadi, Carine Tellier-Lebègue, Clément Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean-Baptiste Charbonnier, Mauro Modesti
Published 2016-10-01

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

by Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun
Published 2020-02-01

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

by Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, Eli Rothenberg
Published 2021-05-01

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

by Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A. Schmid, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Published 2020-07-01

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.

by Edwige B Garcin, Stéphanie Gon, Meghan R Sullivan, Gregory J Brunette, Anne De Cian, Jean-Paul Concordet, Carine Giovannangeli, Wilhelm G Dirks, Sonja Eberth, Kara A Bernstein, Rohit Prakash, Maria Jasin, Mauro Modesti
Published 2019-10-01

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC)

by Audrey Benyamine, Céline Loncle, Etienne Foucher, Juan-Luis Blazquez, Céline Castanier, Anne-Sophie Chrétien, Mauro Modesti, Véronique Secq, Salem Chouaib, Meritxell Gironella, Elena Vila-Navarro, Giuseppe Montalto, Jean-Charles Dagorn, Nelson Dusetti, Juan Iovanna, Daniel Olive
Published 2018-01-01

Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex

by Rohit Prakash, Thomas Sandoval, Florian Morati, Jennifer A. Zagelbaum, Pei-Xin Lim, Travis White, Brett Taylor, Raymond Wang, Emilie C. B. Desclos, Meghan R. Sullivan, Hayley L. Rein, Kara A. Bernstein, Przemek M. Krawczyk, Jean Gautier, Mauro Modesti, Fabio Vanoli, Maria Jasin
Published 2021-07-01