Finding new collaboration models for enabling neglected tropical disease drug discovery.

by Michael P Pollastri
Published 2014-07-01

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target.

by Stefan Kunz, Vreni Balmer, Geert Jan Sterk, Michael P Pollastri, Rob Leurs, Norbert Müller, Andrew Hemphill, Cornelia Spycher
Published 2017-09-01

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

by Sabrina Absalon, Karin Blomqvist, Rachel M. Rudlaff, Travis J. DeLano, Michael P. Pollastri, Jeffrey D. Dvorin, Louis H. Miller
Published 2018-02-01

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.

by Brendan D Galvin, Zhiru Li, Estelle Villemaine, Catherine B Poole, Melissa S Chapman, Michael P Pollastri, Paul G Wyatt, Clotilde K S Carlow
Published 2014-09-01

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

by Rosario Diaz-Gonzalez, F Matthew Kuhlmann, Cristina Galan-Rodriguez, Luciana Madeira da Silva, Manuel Saldivia, Caitlin E Karver, Ana Rodriguez, Stephen M Beverley, Miguel Navarro, Michael P Pollastri
Published 2011-08-01

Anilinoquinoline based inhibitors of trypanosomatid proliferation.

by Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Kirsten Gillingwater, Michael P Pollastri
Published 2018-11-01

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

by Margaret M Lowe, Jeff E Mold, Bittoo Kanwar, Yong Huang, Alexander Louie, Michael P Pollastri, Cuihua Wang, Gautam Patel, Diana G Franks, Jennifer Schlezinger, David H Sherr, Allen E Silverstone, Mark E Hahn, Joseph M McCune
Published 2014-01-01

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

by Rosario Diaz, Sandra A Luengo-Arratta, João D Seixas, Emanuele Amata, William Devine, Carlos Cordon-Obras, Domingo I Rojas-Barros, Elena Jimenez, Fatima Ortega, Sabrinia Crouch, Gonzalo Colmenarejo, Jose Maria Fiandor, Jose Julio Martin, Manuela Berlanga, Silvia Gonzalez, Pilar Manzano, Miguel Navarro, Michael P Pollastri
Published 2014-10-01

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

by Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri
Published 2019-02-01