Epigenetic Drifts during Long-Term Intestinal Organoid Culture

by Torsten Thalheim, Susann Siebert, Marianne Quaas, Maria Herberg, Michal R. Schweiger, Gabriela Aust, Joerg Galle
Published 2021-07-01

Impact of Acute Aerobic Exercise on Genome-Wide DNA-Methylation in Natural Killer Cells—A Pilot Study

by Alexander Schenk, Christine Koliamitra, Claus Jürgen Bauer, Robert Schier, Michal R. Schweiger, Wilhelm Bloch, Philipp Zimmer
Published 2019-05-01

Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis.

by Michal R Schweiger, Martin Kerick, Bernd Timmermann, Marcus W Albrecht, Tatjana Borodina, Dmitri Parkhomchuk, Kurt Zatloukal, Hans Lehrach
Published 2009-01-01

Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells

by Torsten Thalheim, Lydia Hopp, Maria Herberg, Susann Siebert, Christiane Kerner, Marianne Quaas, Michal R. Schweiger, Gabriela Aust, Joerg Galle
Published 2020-03-01

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine

by Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger, Gabriela Aust
Published 2019-04-01

ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer.

by Lukasz A Kacprzyk, Mark Laible, Tatjana Andrasiuk, Jan C Brase, Stefan T Börno, Maria Fälth, Ruprecht Kuner, Hans Lehrach, Michal R Schweiger, Holger Sültmann
Published 2013-01-01

Altered DNA Methylation Profiles in <i>SF3B1</i> Mutated CLL Patients

by Alicja Pacholewska, Christina Grimm, Carmen D. Herling, Matthias Lienhard, Anja Königs, Bernd Timmermann, Janine Altmüller, Oliver Mücke, Hans Christian Reinhardt, Christoph Plass, Ralf Herwig, Michael Hallek, Michal R. Schweiger
Published 2021-08-01

Pericentromeric Satellite III transcripts induce etoposide resistance

by Julian Kanne, Michelle Hussong, Jörg Isensee, Álvaro Muñoz-López, Jan Wolffgramm, Felix Heß, Christina Grimm, Sergey Bessonov, Lydia Meder, Jie Wang, H. Christian Reinhardt, Margarete Odenthal, Tim Hucho, Reinhard Büttner, Daniel Summerer, Michal R. Schweiger
Published 2021-05-01

DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer.

by Christina Grimm, Lukas Chavez, Mireia Vilardell, Alexandra L Farrall, Sascha Tierling, Julia W Böhm, Phillip Grote, Matthias Lienhard, Jörn Dietrich, Bernd Timmermann, Jörn Walter, Michal R Schweiger, Hans Lehrach, Ralf Herwig, Bernhard G Herrmann, Markus Morkel
Published 2013-01-01

<i>Campylobacter concisus</i> Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption

by Praveen Kumar Nattramilarasu, Roland Bücker, Fábia Daniela Lobo de Sá, Anja Fromm, Oliver Nagel, In-Fah Maria Lee, Eduard Butkevych, Soraya Mousavi, Claudia Genger, Sigri Kløve, Markus M. Heimesaat, Stefan Bereswill, Michal R. Schweiger, Hans Linde Nielsen, Hanno Troeger, Jörg-Dieter Schulzke
Published 2020-01-01

Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis.

by Bernd Timmermann, Martin Kerick, Christina Roehr, Axel Fischer, Melanie Isau, Stefan T Boerno, Andrea Wunderlich, Christian Barmeyer, Petra Seemann, Jana Koenig, Michael Lappe, Andreas W Kuss, Masoud Garshasbi, Lars Bertram, Kathrin Trappe, Martin Werber, Bernhard G Herrmann, Kurt Zatloukal, Hans Lehrach, Michal R Schweiger
Published 2010-01-01

High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications.

by Christina Röhr, Martin Kerick, Axel Fischer, Alexander Kühn, Karl Kashofer, Bernd Timmermann, Andriani Daskalaki, Thomas Meinel, Dmitriy Drichel, Stefan T Börno, Anja Nowka, Sylvia Krobitsch, Alice C McHardy, Christina Kratsch, Tim Becker, Andrea Wunderlich, Christian Barmeyer, Christian Viertler, Kurt Zatloukal, Christoph Wierling, Hans Lehrach, Michal R Schweiger
Published 2013-01-01

Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance

by Sabrina Grasse, Matthias Lienhard, Steffen Frese, Martin Kerick, Anne Steinbach, Christina Grimm, Michelle Hussong, Jana Rolff, Michael Becker, Felix Dreher, Uwe Schirmer, Stefan Boerno, Anna Ramisch, Gunda Leschber, Bernd Timmermann, Christian Grohé, Heike Lüders, Martin Vingron, Iduna Fichtner, Sebastian Klein, Margarete Odenthal, Reinhard Büttner, Hans Lehrach, Holger Sültmann, Ralf Herwig, Michal R. Schweiger
Published 2018-07-01