2,2' azobis 2 methyl propanimidamide A2M protein, human Alpha-2-macroglobulin Antipsychotic Agents Article Binding Sites Clozapine Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Molecular Docking Simulation Oxidation-Reduction Oxidative Stress Protein Binding Protein Conformation Protein-ligand interaction Structure-Activity Relationship alpha 2 macroglobulin alpha-Macroglobulins association constant binding affinity binding site chemical phenomena chemistry clozapine complex formation drug protein binding enzyme activity free radical human