Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.

by Masao Terasawa, Takehito Uruno, Sayako Mori, Mutsuko Kukimoto-Niino, Akihiko Nishikimi, Fumiyuki Sanematsu, Yoshihiko Tanaka, Shigeyuki Yokoyama, Yoshinori Fukui
Published 2012-01-01

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction.

by Takayoshi Matsuda, Takuhiro Ito, Chie Takemoto, Kazushige Katsura, Mariko Ikeda, Motoaki Wakiyama, Mutsuko Kukimoto-Niino, Shigeyuki Yokoyama, Yoshikazu Kurosawa, Mikako Shirouzu
Published 2018-01-01

Reduced efficacy of a Src kinase inhibitor in crowded protein solution

by Kento Kasahara, Suyong Re, Grzegorz Nawrocki, Hiraku Oshima, Chiemi Mishima-Tsumagari, Yukako Miyata-Yabuki, Mutsuko Kukimoto-Niino, Isseki Yu, Mikako Shirouzu, Michael Feig, Yuji Sugita
Published 2021-07-01

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

by Kanako Shimizu, Satoru Yamasaki, Maki Sakurai, Noriko Yumoto, Mariko Ikeda, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Takashi Watanabe, Masami Kawamura, Mikako Shirouzu, Shin-ichiro Fujii
Published 2019-06-01

TNIK inhibition abrogates colorectal cancer stemness

by Mari Masuda, Yuko Uno, Naomi Ohbayashi, Hirokazu Ohata, Ayako Mimata, Mutsuko Kukimoto-Niino, Hideki Moriyama, Shigeki Kashimoto, Tomoko Inoue, Naoko Goto, Koji Okamoto, Mikako Shirouzu, Masaaki Sawa, Tesshi Yamada
Published 2016-08-01

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib

by Dr. Naomi Ohbayashi, Dr. Kazutaka Murayama, Miyuki Kato‐Murayama, Dr. Mutsuko Kukimoto‐Niino, Dr. Tamami Uejima, Dr. Takayoshi Matsuda, Dr. Noboru Ohsawa, Prof. Shigeyuki Yokoyama, Prof. Hiroshi Nojima, Dr. Mikako Shirouzu
Published 2018-09-01

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

by Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima, Fumiyuki Sanematsu, Teruki Honma, Takaho Terada, Eiji Oki, Senji Shirasawa, Yoshihiko Maehara, Dongchon Kang, Jean-François Côté, Shigeyuki Yokoyama, Motomu Kanai, Yoshinori Fukui
Published 2017-05-01

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

by Hayato Mizuta, Koutaroh Okada, Mitsugu Araki, Jun Adachi, Ai Takemoto, Justyna Kutkowska, Kohei Maruyama, Noriko Yanagitani, Tomoko Oh-hara, Kana Watanabe, Keiichi Tamai, Luc Friboulet, Kazuhiro Katayama, Biao Ma, Yoko Sasakura, Yukari Sagae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Satoshi Takagi, Siro Simizu, Makoto Nishio, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
Published 2021-02-01