Hydrophobic interactions at subsite S1′ of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides

by Mitsugu Araki, Norimasa Kanegawa, Hiroaki Iwata, Yukari Sagae, Keisuke Ito, Katsuyoshi Masuda, Yasushi Okuno
Published 2020-06-01

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics

by Mitsugu Araki, Shigeyuki Matsumoto, Gert-Jan Bekker, Yuta Isaka, Yukari Sagae, Narutoshi Kamiya, Yasushi Okuno
Published 2021-05-01

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

by Hayato Mizuta, Koutaroh Okada, Mitsugu Araki, Jun Adachi, Ai Takemoto, Justyna Kutkowska, Kohei Maruyama, Noriko Yanagitani, Tomoko Oh-hara, Kana Watanabe, Keiichi Tamai, Luc Friboulet, Kazuhiro Katayama, Biao Ma, Yoko Sasakura, Yukari Sagae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Satoshi Takagi, Siro Simizu, Makoto Nishio, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
Published 2021-02-01