MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

by Jesus Gonzalo-Asensio, Jesus Gonzalo-Asensio, Dessislava Marinova, Dessislava Marinova, Carlos Martin, Carlos Martin, Carlos Martin, Nacho Aguilo, Nacho Aguilo
Published 2017-12-01

Update on TB Vaccine Pipeline

by Carlos Martin, Nacho Aguilo, Dessislava Marinova, Jesus Gonzalo-Asensio
Published 2020-04-01

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.

by Santiago Uranga, Dessislava Marinova, Carlos Martin, Julián Pardo, Nacho Aguilo
Published 2016-01-01

Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

by Paula Jaime-Sanchez, Iratxe Uranga-Murillo, Nacho Aguilo, Sofia C Khouili, Maykel A Arias
Published 2020-06-01

Natural Killer Anti-Tumor Activity Can Be Achieved by In Vitro Incubation With Heat-Killed BCG

by Gloria Esteso, Nacho Aguiló, Esther Julián, Omodele Ashiru, Mei. M. Ho, Carlos Martín, Mar Valés-Gómez
Published 2021-02-01

Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment

by Raquel Tarancón, Elena Mata, Santiago Uranga, Ana Belén Gómez, Dessislava Marinova, Isabel Otal, Carlos Martín, Nacho Aguiló
Published 2021-02-01

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

by Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Published 2020-05-01

New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages.

by Jesús Gonzalo-Asensio, Irene Pérez, Nacho Aguiló, Santiago Uranga, Ana Picó, Carlos Lampreave, Alberto Cebollada, Isabel Otal, Sofía Samper, Carlos Martín
Published 2018-04-01

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

by Esther Broset, Narcís Saubi, Núria Guitart, Nacho Aguilo, Santiago Uranga, Athina Kilpeläinen, Yoshiki Eto, Tomáš Hanke, Jesús Gonzalo-Asensio, Carlos Martín, Joan Joseph-Munné
Published 2019-06-01

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

by Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin
Published 2017-07-01

Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

by Nacho Aguilo, Nacho Aguilo, Santiago Uranga, Santiago Uranga, Elena Mata, Elena Mata, Raquel Tarancon, Raquel Tarancon, Ana Belén Gómez, Ana Belén Gómez, Dessislava Marinova, Dessislava Marinova, Isabel Otal, Isabel Otal, Marta Monzón, Juan Badiola, Dolores Montenegro, Eugenia Puentes, Esteban Rodríguez, Richard A. W. Vervenne, Claudia C. Sombroek, Frank A. W. Verreck, Carlos Martín, Carlos Martín, Carlos Martín
Published 2020-06-01

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.

by Elena Mata, Damien Farrell, Ruoyao Ma, Santiago Uranga, Ana Belen Gomez, Marta Monzon, Juan Badiola, Alberto Anel, Jesús Gonzalo-Asensio, Carlos Martin, Stephen V Gordon, Nacho Aguilo
Published 2020-12-01

Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

by Maykel A. Arias, María P. Jiménez de Bagües, Nacho Aguiló, Sebastián Menao, Sandra Hervás-Stubbs, Alba de Martino, Ana Alcaraz, Markus M. Simon, Christopher J. Froelich, Julián Pardo
Published 2014-07-01

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.

by Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V Ferreira, Laszlo A Groh, Mirian Domenech, Fernando González-Camacho, Niels P Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G Netea
Published 2020-04-01

BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

by Esther Broset, Jacobo Pardo-Seco, Alex I. Kanno, Nacho Aguilo, Ana Isabel Dacosta, Irene Rivero-Calle, Jesus Gonzalo-Asensio, Camille Locht, Luciana C.C. Leite, Carlos Martin, Federico Martinón-Torres
Published 2021-03-01

Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

by Alvaro Roy, Irene Tomé, Beatriz Romero, Víctor Lorente-Leal, José A. Infantes-Lorenzo, Mercedes Domínguez, Carlos Martín, Nacho Aguiló, Eugenia Puentes, Esteban Rodríguez, Lucía de Juan, María A. Risalde, Christian Gortázar, Lucas Domínguez, Javier Bezos
Published 2019-10-01

Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-...

by Llipsy Santiago, Iratxe Uranga-Murillo, Maykel Arias, Andrés Manuel González-Ramírez, Javier Macías-León, Eduardo Moreo, Sergio Redrado, Ana García-García, Víctor Taleb, Erandi Lira-Navarrete, Ramón Hurtado-Guerrero, Nacho Aguilo, Maria del Mar Encabo-Berzosa, Sandra Hidalgo, Eva M. Galvez, Ariel Ramirez-Labrada, Diego de Miguel, Rafael Benito, Patricia Miranda, Antonio Fernández, José María Domingo, Laura Serrano, Cristina Yuste, Sergio Villanueva-Saz, José Ramón Paño-Pardo, Julián Pardo
Published 2021-03-01

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

by Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Olivier Neyrolles, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Steffen Stenger, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, François Spertini, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Nick Drager, Danielle Roordink, Jelle Thole, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Mei Mei Ho, Helen McShane, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Published 2017-10-01