The impact of rare and low-frequency genetic variants in common disease

by Lorenzo Bomba, Klaudia Walter, Nicole Soranzo
Published 2017-04-01

Synthetic associations are unlikely to account for many common disease genome-wide association signals.

by Carl A Anderson, Nicole Soranzo, Eleftheria Zeggini, Jeffrey C Barrett
Published 2011-01-01

Personalized and graph genomes reveal missing signal in epigenomic data

by Cristian Groza, Tony Kwan, Nicole Soranzo, Tomi Pastinen, Guillaume Bourque
Published 2020-05-01

Ancient and recent positive selection transformed opioid cis-regulation in humans.

by Matthew V Rockman, Matthew W Hahn, Nicole Soranzo, Fritz Zimprich, David B Goldstein, Gregory A Wray
Published 2005-12-01

A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

by Ewa Bielczyk-Maczyńska, Jovana Serbanovic-Canic, Lauren Ferreira, Nicole Soranzo, Derek L Stemple, Willem H Ouwehand, Ana Cvejic
Published 2014-07-01

Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms.

by Idil Yet, Cristina Menni, So-Youn Shin, Massimo Mangino, Nicole Soranzo, Jerzy Adamski, Karsten Suhre, Tim D Spector, Gabi Kastenmüller, Jordana T Bell
Published 2016-01-01

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

by Na Cai, Na Cai, Monika Fňašková, Monika Fňašková, Klára Konečná, Klára Konečná, Miloslava Fojtová, Miloslava Fojtová, Jiří Fajkus, Jiří Fajkus, Eve Coomber, Stephen Watt, Nicole Soranzo, Marek Preiss, Ivan Rektor
Published 2020-03-01

A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

by Fumihiko Takeuchi, Ralph McGinnis, Stephane Bourgeois, Chris Barnes, Niclas Eriksson, Nicole Soranzo, Pamela Whittaker, Venkatesh Ranganath, Vasudev Kumanduri, William McLaren, Lennart Holm, Jonatan Lindh, Anders Rane, Mia Wadelius, Panos Deloukas
Published 2009-03-01

The influence of rare variants in circulating metabolic biomarkers.

by Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Published 2020-03-01

Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits.

by Dirk S. Paul, James P. Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R. Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D. Trip, Berthold Göttgens, Nicole Soranzo, Willem H. Ouwehand, Panos Deloukas
Published 2011-07-01

The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.

by Alexander W Drong, George Nicholson, Asa K Hedman, Eshwar Meduri, Elin Grundberg, Kerrin S Small, So-Youn Shin, Jordana T Bell, Fredrik Karpe, Nicole Soranzo, Tim D Spector, Mark I McCarthy, Panos Deloukas, Mattias Rantalainen, Cecilia M Lindgren, MolPAGE Consortia
Published 2013-01-01

Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

by Dirk S. Paul, James P. Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R. Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D. Trip, Consortium Cardiogenics, Consortium MuTHER, Berthold Göttgens, Nicole Soranzo, Willem H. Ouwehand, Panos Deloukas
Published 2011-07-01

Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.

by Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas
Published 2011-06-01

Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.

by Giorgio Pistis, Shawntel U Okonkwo, Michela Traglia, Cinzia Sala, So-Youn Shin, Corrado Masciullo, Iwan Buetti, Roberto Massacane, Massimo Mangino, Swee-Lay Thein, Timothy D Spector, Santhi Ganesh, CHARGE Consortium Hematology Working, Nicola Pirastu, Paolo Gasparini, Nicole Soranzo, Clara Camaschella, Daniel Hart, Michael R Green, Daniela Toniolo
Published 2013-01-01

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

by Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Published 2021-07-01

The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.

by Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, John Broxholme, Kourosh R Ahmadi, Gabriela L Surdulescu, Ernesto Lowy, Christian Gieger, Chris Newton-Cheh, Markus Perola, Nicole Soranzo, Ida Surakka, Cecilia M Lindgren, Jiannis Ragoussis, Andrew P Morris, Lon R Cardon, Tim D Spector, Krina T Zondervan
Published 2011-01-01

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

by Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert
Published 2016-04-01

Correction: Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

by Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert
Published 2017-07-01

Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

by Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F. Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini
Published 2017-06-01

Correction: Identification of PLCL1 Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study

by Yao-Zhong Liu, Scott G. Wilson, Liang Wang, Xiao-Gang Liu, Yan-Fang Guo, Jian Li, Han Yan, Panos Deloukas, Nicole Soranzo, Usha Chinappen-Horsley, Alessandra Cervino, Frances M. Williams, Dong-Hai Xiong, Yin-Ping Zhang, Tian-Bo Jin, Shawn Levy, Christopher J. Papasian, Betty M. Drees, James J. Hamilton, Robert R. Recker, Tim D. Spector, Hong-Wen Deng
Published 2009-01-01