Hyperactivation of Oncogenic JAK3 Mutants Depend on ATP Binding to the Pseudokinase Domain

by Juuli Raivola, Henrik M. Hammarén, Anniina T. Virtanen, Vilasha Bulleeraz, Vilasha Bulleeraz, Alister C. Ward, Alister C. Ward, Olli Silvennoinen, Olli Silvennoinen, Olli Silvennoinen
Published 2018-12-01

Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling

by Juuli Raivola, Teemu Haikarainen, Olli Silvennoinen
Published 2019-12-01

Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

by Maaria Palmroth, Krista Kuuliala, Ritva Peltomaa, Anniina Virtanen, Antti Kuuliala, Antti Kurttila, Anna Kinnunen, Marjatta Leirisalo-Repo, Olli Silvennoinen, Olli Silvennoinen, Olli Silvennoinen, Pia Isomäki, Pia Isomäki
Published 2021-09-01

Janus Kinases in Leukemia

by Juuli Raivola, Teemu Haikarainen, Bobin George Abraham, Olli Silvennoinen
Published 2021-02-01

Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation.

by Arturo Sanz, Daniela Ungureanu, Tuija Pekkala, Rob Ruijtenbeek, Ivo P Touw, Riet Hilhorst, Olli Silvennoinen
Published 2011-01-01

<i>IRF2BP2</i> Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

by Maaria Palmroth, Hanna Viskari, Mikko R. J. Seppänen, Salla Keskitalo, Anniina Virtanen, Markku Varjosalo, Olli Silvennoinen, Pia Isomäki
Published 2021-08-01

Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.

by Kirsi Kujala, Jere Paavola, Anna Lahti, Kim Larsson, Mari Pekkanen-Mattila, Matti Viitasalo, Annukka M Lahtinen, Lauri Toivonen, Kimmo Kontula, Heikki Swan, Mika Laine, Olli Silvennoinen, Katriina Aalto-Setälä
Published 2012-01-01

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

by Anna L. Lahti, Ville J. Kujala, Hugh Chapman, Ari-Pekka Koivisto, Mari Pekkanen-Mattila, Erja Kerkelä, Jari Hyttinen, Kimmo Kontula, Heikki Swan, Bruce R. Conklin, Shinya Yamanaka, Olli Silvennoinen, Katriina Aalto-Setälä
Published 2012-03-01

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

by Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Published 2017-04-01