Association of host protein VARICOSE with HCPro within a multiprotein complex is crucial for RNA silencing suppression, translation, encapsidation and systemic spread of potato vir...

by Swarnalok De, Maija Pollari, Markku Varjosalo, Kristiina Mäkinen
Published 2020-10-01

Molecular pathogenesis of rhegmatogenous retinal detachment

by Tiina Öhman, Lisa Gawriyski, Sini Miettinen, Markku Varjosalo, Sirpa Loukovaara
Published 2021-01-01

Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes

by Tiina Öhman, Jaakko Teppo, Neeta Datta, Selina Mäkinen, Markku Varjosalo, Heikki A. Koistinen
Published 2021-07-01

Nuclear proteome of virus-infected and healthy potato leaves

by Minna-Liisa Rajamäki, Sidona Sikorskaite-Gudziuniene, Nandita Sarmah, Markku Varjosalo, Jari P. T. Valkonen
Published 2020-07-01

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

by Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo
Published 2018-03-01

The Protein Interaction Landscape of the Human CMGC Kinase Group

by Markku Varjosalo, Salla Keskitalo, Audrey Van Drogen, Helka Nurkkala, Anton Vichalkovski, Ruedi Aebersold, Matthias Gstaiger
Published 2013-04-01

MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

by Venkatram Yellapragada, Venkatram Yellapragada, Xiaonan Liu, Xiaonan Liu, Carina Lund, Carina Lund, Johanna Känsäkoski, Kristiina Pulli, Kristiina Pulli, Sanna Vuoristo, Karolina Lundin, Timo Tuuri, Markku Varjosalo, Markku Varjosalo, Taneli Raivio, Taneli Raivio, Taneli Raivio
Published 2019-02-01

<i>IRF2BP2</i> Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

by Maaria Palmroth, Hanna Viskari, Mikko R. J. Seppänen, Salla Keskitalo, Anniina Virtanen, Markku Varjosalo, Olli Silvennoinen, Pia Isomäki
Published 2021-08-01

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases

by Tahira Anwar, Xiaonan Liu, Taina Suntio, Annika Marjamäki, Joanna Biazik, Edmond Y. W. Chan, Markku Varjosalo, Eeva-Liisa Eskelinen
Published 2019-05-01

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

by Leena Yadav, Elina Pietilä, Tiina Öhman, Xiaonan Liu, Arun K. Mahato, Yulia Sidorova, Kaisa Lehti, Mart Saarma, Markku Varjosalo
Published 2020-02-01

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

by Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen
Published 2015-06-01

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage

by Simon G. Pfisterer, Gergana Gateva, Peter Horvath, Juho Pirhonen, Veijo T. Salo, Leena Karhinen, Markku Varjosalo, Samppa J. Ryhänen, Pekka Lappalainen, Elina Ikonen
Published 2017-03-01

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

by Fang Cheng, Magdalena Weidner-Glunde, Markku Varjosalo, Eeva-Marja Rainio, Anne Lehtonen, Thomas F Schulz, Päivi J Koskinen, Jussi Taipale, Päivi M Ojala
Published 2009-03-01

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

by Katri Korpela, Anne Salonen, Outi Vepsäläinen, Marjo Suomalainen, Carolin Kolmeder, Markku Varjosalo, Sini Miettinen, Kaarina Kukkonen, Erkki Savilahti, Mikael Kuitunen, Willem M de Vos
Published 2018-10-01

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

by Svetlana Konovalova, Xiaonan Liu, Pooja Manjunath, Sundar Baral, Nirajan Neupane, Taru Hilander, Yang Yang, Diego Balboa, Mügen Terzioglu, Liliya Euro, Markku Varjosalo, Henna Tyynismaa
Published 2018-10-01

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

by Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Published 2021-03-01

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated...

by Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä, Eemeli Moisio, Juha R. Savinainen, Jarmo T. Laitinen
Published 2020-03-01

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

by Giuseppe Balistreri, Johanna Viiliäinen, Mikko Turunen, Raquel Diaz, Lauri Lyly, Pirita Pekkonen, Juha Rantala, Krista Ojala, Grzegorz Sarek, Mari Teesalu, Oxana Denisova, Karita Peltonen, Ilkka Julkunen, Markku Varjosalo, Denis Kainov, Olli Kallioniemi, Marikki Laiho, Jussi Taipale, Sampsa Hautaniemi, Päivi M Ojala
Published 2016-02-01

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

by Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Published 2017-04-01

Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

by Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer
Published 2014-05-01