Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function...

by Kerstin Buck, Natalie Landeck, Ayse Ulusoy, Nour K. Majbour, Omar M.A. El-Agnaf, Deniz Kirik
Published 2015-06-01

Decrease in plasma levels of α-synuclein is evident in patients with Parkinson's disease after elimination of heterophilic antibody interference.

by Ryotaro Ishii, Takahiko Tokuda, Harutsugu Tatebe, Takuma Ohmichi, Takashi Kasai, Masanori Nakagawa, Toshiki Mizuno, Omar M A El-Agnaf
Published 2015-01-01

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

by Ilaria Poggiolini, Daniel Erskine, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Christopher M. Morris, Omar M. A. El-Agnaf
Published 2021-05-01

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

by Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia-Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M. A. El-Agnaf
Published 2021-06-01

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.

by Vijay Gupta, Indulekha P Sudhakaran, Zeyaul Islam, Nishant N Vaikath, Issam Hmila, Tamas Lukacsovich, Prasanna R Kolatkar, Omar M A El-Agnaf
Published 2020-01-01

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

by Brian Spencer, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Omar M.A. El-Agnaf, Changyoun Kim, Eliezer Masliah, Robert A. Rissman
Published 2019-07-01

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

by Hidetomo Murakami, Takahiko Tokuda, Omar M. A. El-Agnaf, Takuma Ohmichi, Ayako Miki, Hideaki Ohashi, Yoshiyuki Owan, Yu Saito, Satoshi Yano, Tamao Tsukie, Takeshi Ikeuchi, Kenjiro Ono
Published 2019-06-01

Factors influencing the measurement of lysosomal enzymes activity in human cerebrospinal fluid.

by Emanuele Persichetti, Davide Chiasserini, Lucilla Parnetti, Paolo Eusebi, Silvia Paciotti, Claudia De Carlo, Michela Codini, Nicola Tambasco, Aroldo Rossi, Omar M A El-Agnaf, Paolo Calabresi, Tommaso Beccari
Published 2014-01-01

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

by Marija Dulovic, Maja Jovanovic, Maria Xilouri, Leonidas Stefanis, Ljubica Harhaji-Trajkovic, Tamara Kravic-Stevovic, Verica Paunovic, Mustafa T. Ardah, Omar M.A. El-Agnaf, Vladimir Kostic, Ivanka Markovic, Vladimir Trajkovic
Published 2014-03-01

Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?

by Satoshi Sakaue, Takashi Kasai, Ikuko Mizuta, Masaya Suematsu, Shinya Osone, Yumiko Azuma, Toshihiko Imamura, Takahiko Tokuda, Hitoshi Kanno, Omar M. A. El-Agnaf, Masafumi Morimoto, Masanori Nakagawa, Hajime Hosoi, Toshiki Mizuno
Published 2017-03-01

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

by Mustafa T. Ardah, Simona S. Ghanem, Sara A. Abdulla, Guohua Lv, Mohamed M. Emara, Katerina E. Paleologou, Nishant N. Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M. A. El-Agnaf
Published 2020-03-01

Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers.

by Ana Gorostidi, Alberto Bergareche, Javier Ruiz-Martínez, José F Martí-Massó, María Cruz, Shiji Varghese, Mohamed M Qureshi, Fatimah Alzahmi, Abdulmonem Al-Hayani, Adolfo López de Munáin, Omar M A El-Agnaf
Published 2012-01-01

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

by Mustafa T. Ardah, Katerina E. Paleologou, Guohua Lv, Sindhu A. Menon, Salema B. Abul Khair, Jia-Hong Lu, Bared Safieh-Garabedian, Abdulmonem A. Al-Hayani, David Eliezer, Min Li, Omar M.A. El-Agnaf
Published 2015-02-01

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

by Nour K. Majbour, Jan O. Aasly, Eldbjørg Hustad, Mercy A. Thomas, Nishant N. Vaikath, Naser Elkum, Wilma D. J. van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse, Omar M. A. El-Agnaf
Published 2020-05-01

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed...

by Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell
Published 2019-10-01

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

by Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Published 2018-05-01

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

by Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Published 2018-05-01

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

by Nishant N. Vaikath, Nour K. Majbour, Katerina E. Paleologou, Mustafa T. Ardah, Esther van Dam, Wilma D.J. van de Berg, Shelley L. Forrest, Laura Parkkinen, Wei-Ping Gai, Nobutaka Hattori, Masashi Takanashi, Seung-Jae Lee, David M.A. Mann, Yuzuru Imai, Glenda M. Halliday, Jia-Yi. Li, Omar M.A. El-Agnaf
Published 2015-07-01

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

by Muneerah Smith, Houari B. Abdesselem, Michelle Mullins, Ti-Myen Tan, Andrew J. M. Nel, Maryam A. Y. Al-Nesf, Ilham Bensmail, Nour K. Majbour, Nishant N. Vaikath, Adviti Naik, Khalid Ouararhni, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Darien T. Schell, Seanantha S. Baros-Steyl, Nur D. Anuar, Nur H. Ismail, Priscilla E. Morris, Raja N. R. Mamat, Nurul S. M. Rosli, Arif Anwar, Kavithambigai Ellan, Rozainanee M. Zain, Wendy A. Burgers, Elizabeth S. Mayne, Omar M. A. El-Agnaf, Jonathan M. Blackburn
Published 2021-04-01