The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke

by Valeria Valsecchi, Giusy Laudati, Ornella Cuomo, Rossana Sirabella, Lucio Annunziato, Giuseppe Pignataro
Published 2021-04-01

Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neuro...

by Maria Josè Sisalli, Gaetano Ianniello, Claudia Savoia, Ornella Cuomo, Lucio Annunziato, Antonella Scorziello
Published 2020-03-01

nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion

by Giuseppe Pignataro, Elga Esposito, Rossana Sirabella, Antonio Vinciguerra, Ornella Cuomo, Gianfranco Di Renzo, Lucio Annunziato
Published 2013-06-01

The antiepileptic drug levetiracetam suppresses non-convulsive seizure activity and reduces ischemic brain damage in rats subjected to permanent middle cerebral artery occlusion.

by Ornella Cuomo, Vincenzo Rispoli, Antonio Leo, Giovanni Bosco Politi, Antonio Vinciguerra, Gianfranco di Renzo, Mauro Cataldi
Published 2013-01-01

Corrigendum to “NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia” [Neurobiol. Dis. 45 (2012) 616–623]

by Giuseppe Pignataro, Francesca Boscia, Elga Esposito, Rossana Sirabella, Ornella Cuomo, Antonio Vinciguerra, Gianfranco Di Renzo, Lucio Annunziato
Published 2017-02-01

NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia

by Giuseppe Pignataro, Francesca Boscia, Elga Esposito, Rossana Sirabella, Ornella Cuomo, Antonio Vinciguerra, Gianfranco Di Renzo, Lucio Annunziato
Published 2012-01-01

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

by Annamaria Lanzillotta, Giuseppe Pignataro, Caterina Branca, Ornella Cuomo, Ilenia Sarnico, Marina Benarese, Lucio Annunziato, PierFranco Spano, Marina Pizzi
Published 2013-01-01

Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells.

by Luca Sanguigno, Antonella Casamassa, Niccola Funel, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Francesca Boscia, Paola Brancaccio, Luca Emanuele Pollina, Serenella Anzilotti, Gianfranco Di Renzo, Ornella Cuomo
Published 2018-01-01

Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

by Lara Faggi, Giuseppe Pignataro, Edoardo Parrella, Vanessa Porrini, Antonio Vinciguerra, Pasquale Cepparulo, Ornella Cuomo, Annamaria Lanzillotta, Mariana Mota, Marina Benarese, Paolo Tonin, Lucio Annunziato, PierFranco Spano, Marina Pizzi
Published 2018-01-01

Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

by Ornella Cuomo, Pasquale Cepparulo, Serenella Anzilotti, Angelo Serani, Rossana Sirabella, Paola Brancaccio, Natascia Guida, Valeria Valsecchi, Antonio Vinciguerra, Pasquale Molinaro, Luigi Formisano, Lucio Annunziato, Giuseppe Pignataro, MD PhD
Published 2019-12-01

Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model

by Serenella Anzilotti, Valeria Valsecchi, Paola Brancaccio, Natascia Guida, Giusy Laudati, Valentina Tedeschi, Tiziana Petrozziello, Francesco Frecentese, Elisa Magli, Brenda Hassler, Ornella Cuomo, Luigi Formisano, Agnese Secondo, Lucio Annunziato, Giuseppe Pignataro
Published 2021-11-01

Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets

by Rossana Sirabella, Rossana Sirabella, Valeria Valsecchi, Serenella Anzilotti, Ornella Cuomo, Antonio Vinciguerra, Pasquale Cepparulo, Paola Brancaccio, Natascia Guida, Nicolas Blondeau, Lorella M. T. Canzoniero, Cristina Franco, Salvatore Amoroso, Lucio Annunziato, Giuseppe Pignataro
Published 2018-08-01