Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

by Yuri Ciervo, Ke Ning, Xu Jun, Pamela J. Shaw, Richard J. Mead
Published 2017-11-01

An Objective Functional Characterisation of Head Movement Impairment in Individuals with Neck Muscle Weakness Due to Amyotrophic Lateral Sclerosis.

by Silvia Pancani, Wendy Tindale, Pamela J Shaw, Christopher J McDermott, Claudia Mazzà
Published 2017-01-01

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

by Pamela J. Shaw, Kurt J. De Vos, Christopher P. Webster, Emma F. Smith
Published 2017-05-01

Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS)

by Jodie A. Watkins, James J. P. Alix, Pamela J. Shaw, Richard J. Mead
Published 2021-08-01

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.

by Ellen J Bennett, Richard J Mead, Mimoun Azzouz, Pamela J Shaw, Andrew J Grierson
Published 2014-01-01

Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity

by Rachel Waller, Matthew Wyles, Paul R. Heath, Mbombe Kazoka, Helen Wollff, Pamela J. Shaw, Janine Kirby
Published 2018-01-01

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS

by Yuri Ciervo, Noemi Gatto, Chloe Allen, Andrew Grierson, Laura Ferraiuolo, Richard J. Mead, Pamela J. Shaw
Published 2021-06-01

Proteomic Approaches to Study Cysteine Oxidation: Applications in Neurodegenerative Diseases

by Trong Khoa Pham, Trong Khoa Pham, Weronika A. Buczek, Richard J. Mead, Pamela J. Shaw, Mark O. Collins
Published 2021-06-01

Comparison of blood RNA extraction methods used for gene expression profiling in amyotrophic lateral sclerosis.

by Nadhim Bayatti, Johnathan Cooper-Knock, Joanna J Bury, Matthew Wyles, Paul R Heath, Janine Kirby, Pamela J Shaw
Published 2014-01-01

A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screeni...

by Marc M. J. Da Costa, Claire E. Allen, Adrian Higginbottom, Tennore Ramesh, Pamela J. Shaw, Christopher J. McDermott
Published 2014-01-01

Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?

by Simon M. Bell, Katy Barnes, Matteo De Marco, Pamela J. Shaw, Laura Ferraiuolo, Daniel J. Blackburn, Annalena Venneri, Heather Mortiboys
Published 2021-01-01

Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer’s Disease

by Simon M. Bell, Matteo De Marco, Katy Barnes, Pamela J. Shaw, Laura Ferraiuolo, Daniel J. Blackburn, Heather Mortiboys, Annalena Venneri
Published 2020-04-01

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.

by Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili
Published 2016-01-01

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

by Matthew P. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, Evlyn James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore M. Ramesh
Published 2018-11-01

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

by Katie Richardson, Scott P Allen, Heather Mortiboys, Andrew J Grierson, Stephen B Wharton, Paul G Ince, Pamela J Shaw, Paul R Heath
Published 2013-01-01

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

by Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott
Published 2021-01-01

Biomarkers in Motor Neuron Disease: A State of the Art Review

by Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins, Pamela J. Shaw
Published 2019-04-01

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis.

by Johnathan Cooper-Knock, Joanna J Bury, Paul R Heath, Matthew Wyles, Adrian Higginbottom, Catherine Gelsthorpe, J Robin Highley, Guillaume Hautbergue, Magnus Rattray, Janine Kirby, Pamela J Shaw
Published 2015-01-01

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

by Richard J Mead, Ellen J Bennett, Aneurin J Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson, Pamela J Shaw
Published 2011-01-01

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

by Joanna J. Bury, Annabelle Chambers, Paul R. Heath, Paul G. Ince, Pamela J. Shaw, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton, the Cognitive Function and Ageing Study
Published 2021-01-01