AAV9‐mediated AIRE gene delivery clears circulating antibodies and tissue T‐cell infiltration in a mouse model of autoimmune polyglandular syndrome type‐1

by Sarah Almaghrabi, Mimoun Azzouz, Rachid Tazi Ahnini
Published 2020-01-01

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1G93A transgenic mice

by Sandrine Guillot, Mimoun Azzouz, Nicole Déglon, Anne Zurn, Patrick Aebischer
Published 2004-06-01

AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

by Vera Lukashchuk, Katherine E Lewis, Ian Coldicott, Andrew J Grierson, Mimoun Azzouz
Published 2016-01-01

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.

by Ellen J Bennett, Richard J Mead, Mimoun Azzouz, Pamela J Shaw, Andrew J Grierson
Published 2014-01-01

Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy

by Aziza Alrafiah, Evangelia Karyka, Ian Coldicott, Kayleigh Iremonger, Katherin E. Lewis, Ke Ning, Mimoun Azzouz
Published 2018-06-01

The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus.

by Thomas R J Lovewell, Andrew J McDonagh, Andrew G Messenger, Mimoun Azzouz, Rachid Tazi-Ahnini
Published 2015-01-01

Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating STAT1 and...

by Thomas R. J. Lovewell, Andrew J. G. McDonagh, Andrew G. Messenger, Mimoun Azzouz, Rachid Tazi-Ahnini
Published 2018-06-01

Electromyographical and Motor Performance Studies in thepmnMouse Model of Neurodegenerative Disease

by Philippe F. Kennel, Paul Fonteneau, Elisabeth Martin, Jean-Marc Schmidt, Mimoun Azzouz, Jacques Borg, Jean-Louis Guenet, Henning Schmalbruch, Jean-Marie Warter, Philippe Poindron
Published 1996-04-01

Identification of single nucleotide variants in the Moroccan population by whole-genome sequencing

by Lucy Crooks, Johnathan Cooper-Knock, Paul R. Heath, Ahmed Bouhouche, Mostafa Elfahime, Mimoun Azzouz, Youssef Bakri, Mohammed Adnaoui, Azeddine Ibrahimi, Saaïd Amzazi, Rachid Tazi-Ahnini
Published 2020-09-01

Trophic activity of Rabies G protein-pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro

by Qingshan Teng, Mary Garrity-Moses, Thais Federici, Diana Tanase, James K. Liu, Nicholas D. Mazarakis, Mimoun Azzouz, Lucy E. Walmsley, Erin Carlton, Nicholas M. Boulis
Published 2005-12-01

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

by Richard J Mead, Ellen J Bennett, Aneurin J Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson, Pamela J Shaw
Published 2011-01-01

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

by Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, Mimoun Azzouz
Published 2017-07-01

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS

by Tommaso Iannitti, Joseph M. Scarrott, Shibi Likhite, Ian R.P. Coldicott, Katherine E. Lewis, Paul R. Heath, Adrian Higginbottom, Monika A. Myszczynska, Marta Milo, Guillaume M. Hautbergue, Kathrin Meyer, Brian K. Kaspar, Laura Ferraiuolo, Pamela J. Shaw, Mimoun Azzouz
Published 2018-09-01

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

by Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Published 2021-08-01

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

by Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Published 2017-07-01

C9orf72 expansions disrupt ATM-mediated DNA repair

by Walker, Callum
Published 2018