Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical...

by Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs
Published 2020-11-01

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

by Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian M. Isaacs, Vincent Plagnol
Published 2017-05-01

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

by Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge
Published 2019-12-01

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS

by Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, Tammaryn Lashley
Published 2019-02-01

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

by Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M. Isaacs
Published 2017-04-01

The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 1; referees: 1 approved, 2 approved with reservations]

by Justin L. Tosh, Matthew Rickman, Ellie Rhymes, Frances E. Norona, Emma Clayton, Lennart Mucke, Adrian M. Isaacs, Elizabeth M.C. Fisher, Frances K. Wiseman
Published 2017-09-01

The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease [version 2; referees: 1 approved, 2 approved with reservations]

by Justin L. Tosh, Matthew Rickman, Ellie Rhymes, Frances E. Norona, Emma Clayton, Lennart Mucke, Adrian M. Isaacs, Elizabeth M.C. Fisher, Frances K. Wiseman
Published 2018-10-01

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

by Janani Iyer, Qingyu Wang, Thanh Le, Lucilla Pizzo, Sebastian Grönke, Surendra S. Ambegaokar, Yuzuru Imai, Ashutosh Srivastava, Beatriz Llamusí Troisí, Graeme Mardon, Ruben Artero, George R. Jackson, Adrian M. Isaacs, Linda Partridge, Bingwei Lu, Justin P. Kumar, Santhosh Girirajan
Published 2016-05-01

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

by Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge
Published 2021-03-01

Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis

by Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Karina McDade, Karina McDade, Christopher M. Henstridge, Christopher M. Henstridge, Christopher M. Henstridge, Tara L. Spires-Jones, Tara L. Spires-Jones, Tara L. Spires-Jones, Owen G. James, Owen G. James, Owen G. James, Arpan R. Mehta, Arpan R. Mehta, Arpan R. Mehta, David Story, David Story, David Story, Karen Burr, Karen Burr, Karen Burr, Dario Magnani, Dario Magnani, Dario Magnani, Adrian M. Isaacs, Adrian M. Isaacs, Colin Smith, Colin Smith, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran
Published 2021-09-01

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

by Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Published 2017-07-01

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
Published 2018-01-01