Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

by Waijiao Cai, Danielle Feng, Michael A. Schwarzschild, Pamela J. McLean, Xiqun Chen
Published 2018-03-01

A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

by Marion eDelenclos, Teodora eTrendafilova, Daryl R Jones, Simon eMoussaud, Ann Marie eBaine, Mei eYue, Warren D Hirst, Pamela J McLean, Pamela J McLean
Published 2016-01-01

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

by Peizhou Jiang, Ming Gan, Shu-Hui Yen, Pamela J. McLean, Dennis W. Dickson
Published 2017-08-01

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.

by Hemi Dimant, Liya Zhu, Laura N Kibuuka, Zhanyun Fan, Bradley T Hyman, Pamela J McLean
Published 2014-01-01

In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.

by Vivek K Unni, Tamily A Weissman, Edward Rockenstein, Eliezer Masliah, Pamela J McLean, Bradley T Hyman
Published 2010-05-01

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

by Lorraine V Kalia, Suneil K Kalia, Hien Chau, Andres M Lozano, Bradley T Hyman, Pamela J McLean
Published 2011-02-01

Transcriptional dysregulation in a transgenic model of Parkinson disease

by Talene A. Yacoubian, Ippolita Cantuti-Castelvetri, Bérengère Bouzou, Georgios Asteris, Pamela J. McLean, Bradley T. Hyman, David G. Standaert
Published 2008-03-01

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

by Tiago Fleming Outeiro, Preeti Putcha, Julie E. Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T. Hyman, Pamela J. McLean
Published 2008-01-01

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells.

by Tiago Fleming Outeiro, Preeti Putcha, Julie E. Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T. Hyman, Pamela J. McLean
Published 2008-01-01

Formation of toxic oligomeric alpha-synuclein species in living cells.

by Tiago Fleming Outeiro, Preeti Putcha, Julie E Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T Hyman, Pamela J McLean
Published 2008-04-01

Dopamine-induced conformational changes in alpha-synuclein.

by Tiago F Outeiro, Jochen Klucken, Kathryn Bercury, Julie Tetzlaff, Preeti Putcha, Luis M A Oliveira, Alexandre Quintas, Pamela J McLean, Bradley T Hyman
Published 2009-09-01

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

by Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos, Pamela J. McLean
Published 2020-01-01

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

by Marion Delenclos, Ayman H. Faroqi, Mei Yue, Aishe Kurti, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Dennis W. Dickson, John D. Fryer, Pamela J. McLean
Published 2017-06-01

Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease

by Yogesh Bhattarai, Jie Si, Meng Pu, Owen A. Ross, Pamela J. McLean, Lisa Till, William Moor, Madhusudan Grover, Karunya K. Kandimalla, Kara G. Margolis, Gianrico Farrugia, Purna C. Kashyap
Published 2021-01-01

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.

by Nikolaus R McFarland, Hemi Dimant, Laura Kibuuka, Darius Ebrahimi-Fakhari, Cody A Desjardins, Karin M Danzer, Michael Danzer, Zhanyun Fan, Michael A Schwarzschild, Warren Hirst, Pamela J McLean
Published 2014-01-01

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

by Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, So Yeon Koo, Lina Wang, Dianhua Qiao, Jonathan Loi, Andrew J. Petersen, Michael Stockton, Anita Bhattacharyya, Mathew V. Jones, Xinyu Zhao, Pamela J. McLean, Andrew A. Sproul, Krishanu Saha, Subhojit Roy
Published 2019-01-01

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

by Martin Kiechle, Bjoern von Einem, Lennart Höfs, Patrizia Voehringer, Veselin Grozdanov, Daniel Markx, Rosanna Parlato, Diana Wiesner, Benjamin Mayer, Olena Sakk, Bernd Baumann, Soeren Lukassen, Birgit Liss, Arif B. Ekici, Albert C. Ludolph, Paul Walther, Boris Ferger, Pamela J. McLean, Björn H. Falkenburger, Jochen H. Weishaupt, Karin M. Danzer
Published 2019-11-01