Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

by Collin M. Bantle, Warren D. Hirst, Andreas Weihofen, Evgeny Shlevkov
Published 2021-01-01

Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients

by Omar S. Mabrouk, Siwei Chen, Amanda L. Edwards, Minhua Yang, Warren D. Hirst, Danielle L. Graham
Published 2020-05-01

Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.

by Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese, Stephen Noell, David Riddell, Warren D Hirst
Published 2015-01-01

Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.

by Li Li, Sashi Nadanaciva, Zdenek Berger, Wei Shen, Katrina Paumier, Joel Schwartz, Kewa Mou, Paula Loos, Anthony J Milici, John Dunlop, Warren D Hirst
Published 2013-01-01

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.

by Pooja P Pungaliya, Yuchen Bai, Kerri Lipinski, Vasanti S Anand, Saurabh Sen, Eugene L Brown, Brian Bates, Peter H Reinhart, Andrew B West, Warren D Hirst, Steven P Braithwaite
Published 2010-10-01

A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

by Marion eDelenclos, Teodora eTrendafilova, Daryl R Jones, Simon eMoussaud, Ann Marie eBaine, Mei eYue, Warren D Hirst, Pamela J McLean, Pamela J McLean
Published 2016-01-01

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

by Steven P. Braithwaite, Ralf S. Schmid, Dong Ning He, Mei-Li A. Sung, Seongeon Cho, Lynn Resnick, Michael M. Monaghan, Warren D. Hirst, Christian Essrich, Peter H. Reinhart, Donald C. Lo
Published 2010-09-01

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

by Hardy J. Rideout, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans, Jean-Marc Taymans
Published 2020-08-01

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

by Katrina L Paumier, Stacey J Sukoff Rizzo, Zdenek Berger, Yi Chen, Cathleen Gonzales, Edward Kaftan, Li Li, Susan Lotarski, Michael Monaghan, Wei Shen, Polina Stolyar, Dmytro Vasilyev, Margaret Zaleska, Warren D Hirst, John Dunlop
Published 2013-01-01

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

by Andreas Weihofen, YuTing Liu, Joseph W. Arndt, Christian Huy, Chao Quan, Benjamin A. Smith, Jean-Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su, Galina Marsh, Pavan K. Auluck, Fabio Montrasio, Roger M. Nitsch, Warren D. Hirst, Jesse M. Cedarbaum, R. Blake Pepinsky, Jan Grimm, Paul H. Weinreb
Published 2019-04-01

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

by Luis M. A. Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A. Lashuel, David Sulzer, Kostas Vekrellis, Glenda M. Halliday, Julianna J. Tomlinson, Michael Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D. Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago F. Outeiro
Published 2021-07-01

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model.

by Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave
Published 2021-01-01