The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

by Bibhu P. Mishra, Kristin M. Zaffuto, Erika L. Artinger, Tonis Org, Hanna K.A. Mikkola, Chao Cheng, Malek Djabali, Patricia Ernst
Published 2014-05-01

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

by Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Published 2019-09-01

Runx1 loss minimally impacts long-term hematopoietic stem cells.

by Xiongwei Cai, Justin J Gaudet, James K Mangan, Michael J Chen, Maria Elena De Obaldia, Zaw Oo, Patricia Ernst, Nancy A Speck
Published 2011-01-01

Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis

by Weiwei Yang, G. Devon Trahan, Elizabeth D. Howell, Nancy A. Speck, Kenneth L. Jones, Austin E. Gillen, Kent Riemondy, Jay Hesselberth, David Bryder, Patricia Ernst
Published 2020-02-01

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

by David S. Rogawski, Jing Deng, Hao Li, Hongzhi Miao, Dmitry Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Klossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z. Krotoska, Zhuang Jin, Patricia Ernst, Xiaomin Feng, Gang Huang, Kenichi Nishioka, Samantha Kelly, Miao He, Bo Wen, Duxin Sun, Andrew Muntean, Yali Dou, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Published 2021-05-01