Oldies but Goldies mtDNA Population Variants and Neurodegenerative Diseases

by Patrick F. Chinnery, Patrick F. Chinnery, Aurora Gomez-Duran, Aurora Gomez-Duran
Published 2018-10-01

Cell reprogramming shapes the mitochondrial DNA landscape

by Wei Wei, Daniel J. Gaffney, Patrick F. Chinnery
Published 2021-09-01

Correction: Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.

by Wei Wei, Aurora Gomez-Duran, Gavin Hudson, Patrick F Chinnery
Published 2018-05-01

Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.

by Wei Wei, Aurora Gomez-Duran, Gavin Hudson, Patrick F Chinnery
Published 2017-12-01

Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases.

by Gavin Hudson, Aurora Gomez-Duran, Ian J Wilson, Patrick F Chinnery
Published 2014-05-01

Response to Simon et al.,

by Wei Wei, Michael J. Keogh, James W. Ironside, Patrick F. Chinnery
Published 2017-04-01

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

by John D. Widdrington, John D. Widdrington, Aurora Gomez-Duran, Aurora Gomez-Duran, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, Penny E. Lovat, Patrick F. Chinnery, Patrick F. Chinnery, Patrick F. Chinnery, A. John Simpson
Published 2018-09-01

Raised intraocular pressure as a potential risk factor for visual loss in Leber Hereditary Optic Neuropathy.

by Anais Thouin, Philip G Griffiths, Gavin Hudson, Patrick F Chinnery, Patrick Yu-Wai-Man
Published 2013-01-01

The challenges of mitochondrial replacement.

by Patrick F Chinnery, Lyndsey Craven, Shoukhrat Mitalipov, James B Stewart, Mary Herbert, Douglass M Turnbull
Published 2014-04-01

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans.

by Angela Pyle, Gavin Hudson, Ian J Wilson, Jonathan Coxhead, Tania Smertenko, Mary Herbert, Mauro Santibanez-Koref, Patrick F Chinnery
Published 2015-05-01

The Contribution of the Cerebellum to Cognition in Spinocerebellar Ataxia Type 6

by Freya E. Cooper, Manon Grube, Kelly J. Elsegood, John L. Welch, Thomas P. Kelly, Patrick F. Chinnery, Timothy D. Griffiths
Published 2010-01-01

In vivo mitochondrial function in HIV-infected persons treated with contemporary anti-retroviral therapy: a magnetic resonance spectroscopy study.

by Brendan A I Payne, Kieren G Hollingsworth, Joanne Baxter, Edmund Wilkins, Vincent Lee, D Ashley Price, Michael Trenell, Patrick F Chinnery
Published 2014-01-01

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

by Mikael G. Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F. Chinnery
Published 2021-05-01

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old.

by Laura Wiley, Deepthi Ashok, Carmen Martin-Ruiz, Duncan C S Talbot, Joanna Collerton, Andrew Kingston, Karen Davies, Patrick F Chinnery, Michael Catt, Carol Jagger, Thomas B L Kirkwood, Thomas von Zglinicki
Published 2014-01-01

Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function.

by Donna L Nile, Audrey E Brown, Meutia A Kumaheri, Helen R Blair, Alison Heggie, Satomi Miwa, Lynsey M Cree, Brendan Payne, Patrick F Chinnery, Louise Brown, David A Gunn, Mark Walker
Published 2014-01-01

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

by Anna L. Guyatt, Rebecca R. Brennan, Kimberley Burrows, Philip A. I. Guthrie, Raimondo Ascione, Susan M. Ring, Tom R. Gaunt, Angela Pyle, Heather J. Cordell, Debbie A. Lawlor, Patrick F. Chinnery, Gavin Hudson, Santiago Rodriguez
Published 2019-01-01

Extraocular muscle atrophy and central nervous system involvement in chronic progressive external ophthalmoplegia.

by Cynthia Yu-Wai-Man, Fiona E Smith, Michael J Firbank, Grant Guthrie, Stuart Guthrie, Grainne S Gorman, Robert W Taylor, Douglass M Turnbull, Philip G Griffiths, Andrew M Blamire, Patrick F Chinnery, Patrick Yu-Wai-Man
Published 2013-01-01

Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

by Wei Wei, Alistair T. Pagnamenta, Nicholas Gleadall, Alba Sanchis-Juan, Jonathan Stephens, John Broxholme, Salih Tuna, Christopher A. Odhams, Genomics England Research Consortium, NIHR BioResource, Carl Fratter, Ernest Turro, Mark J. Caulfield, Jenny C. Taylor, Shamima Rahman, Patrick F. Chinnery
Published 2020-04-01

High prevalence of focal and multi-focal somatic genetic variants in the human brain

by Michael J. Keogh, Wei Wei, Juvid Aryaman, Lauren Walker, Jelle van den Ameele, Jon Coxhead, Ian Wilson, Matthew Bashton, Jon Beck, John West, Richard Chen, Christian Haudenschild, Gabor Bartha, Shujun Luo, Chris M. Morris, Nick S. Jones, Johannes Attems, Patrick F. Chinnery
Published 2018-10-01

Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.

by Anton K Raap, Roshan S Jahangir Tafrechi, Frans M van de Rijke, Angela Pyle, Carolina Wählby, Karoly Szuhai, Raimond B G Ravelli, René F M de Coo, Harsha K Rajasimha, Mats Nilsson, Patrick F Chinnery, David C Samuels, George M C Janssen
Published 2012-01-01