Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.

by Claire Grills, Nyree Crawford, Alex Chacko, Patrick G Johnston, Francesca O'Rourke, Dean A Fennell
Published 2008-08-01

Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.

by Catherine Wilson, Pamela J Maxwell, Daniel B Longley, Richard H Wilson, Patrick G Johnston, David J J Waugh
Published 2012-01-01

Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway.

by Leanne Stevenson, Wendy L Allen, Irina Proutski, Gail Stewart, Louise Johnston, Karen McCloskey, Peter M Wilson, Daniel B Longley, Patrick G Johnston
Published 2011-01-01

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

by Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Published 2017-05-01

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

by Sandra Van Schaeybroeck, Murugan Kalimutho, Philip D. Dunne, Robbie Carson, Wendy Allen, Puthen V. Jithesh, Keara L. Redmond, Takehiko Sasazuki, Senji Shirasawa, Jaine Blayney, Paolo Michieli, Cathy Fenning, Heinz-Josef Lenz, Mark Lawler, Daniel B. Longley, Patrick G. Johnston
Published 2014-06-01