Therapeutics Targeting the Core Apoptotic Machinery

by Claudia Hamilton, Jennifer P. Fox, Daniel B. Longley, Catherine A. Higgins
Published 2021-05-01

Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.

by Catherine Wilson, Pamela J Maxwell, Daniel B Longley, Richard H Wilson, Patrick G Johnston, David J J Waugh
Published 2012-01-01

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform.

by Anna Matveeva, Michael Fichtner, Katherine McAllister, Christopher McCann, Marc Sturrock, Daniel B Longley, Jochen H M Prehn
Published 2019-09-01

Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway.

by Leanne Stevenson, Wendy L Allen, Irina Proutski, Gail Stewart, Louise Johnston, Karen McCloskey, Peter M Wilson, Daniel B Longley, Patrick G Johnston
Published 2011-01-01

Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression.

by Dario Barbone, Priscilla Cheung, Sailaja Battula, Sara Busacca, Steven G Gray, Daniel B Longley, Raphael Bueno, David J Sugarbaker, Dean A Fennell, V Courtney Broaddus
Published 2012-01-01

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

by Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Published 2017-05-01

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

by Sandra Van Schaeybroeck, Murugan Kalimutho, Philip D. Dunne, Robbie Carson, Wendy Allen, Puthen V. Jithesh, Keara L. Redmond, Takehiko Sasazuki, Senji Shirasawa, Jaine Blayney, Paolo Michieli, Cathy Fenning, Heinz-Josef Lenz, Mark Lawler, Daniel B. Longley, Patrick G. Johnston
Published 2014-06-01

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

by Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally
Published 2021-09-01