Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.

by Erica Werner, Huichen Wang, Paul W Doetsch
Published 2014-01-01

Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation.

by Zhentian Li, David S Yu, Paul W Doetsch, Erica Werner
Published 2020-01-01

Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells.

by Lucy Petrova, Christine Gran, Magnar Bjoras, Paul W Doetsch
Published 2016-01-01

Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli.

by Jordan Morreall, Alice Kim, Yuan Liu, Natalya Degtyareva, Bernard Weiss, Paul W Doetsch
Published 2015-08-01

Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions.

by Rossella Marullo, Erica Werner, Natalya Degtyareva, Bryn Moore, Giuseppe Altavilla, Suresh S Ramalingam, Paul W Doetsch
Published 2013-01-01

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

by Natalya P Degtyareva, Natalie Saini, Joan F Sterling, Victoria C Placentra, Leszek J Klimczak, Dmitry A Gordenin, Paul W Doetsch
Published 2019-05-01

c-Myc Suppression of DNA Double-strand Break Repair

by Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Suresh S. Ramalingam, Paul W. Doetsch, Zhi-Qiang Xiao, Fadlo R. Khuri, Walter J. Curran, Xingming Deng
Published 2012-12-01

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

by Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng
Published 2019-07-01

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

by Hui Zhang, PamelaSara E. Head, Waaqo Daddacha, Seong-Hoon Park, Xingzhe Li, Yunfeng Pan, Matthew Z. Madden, Duc M. Duong, Maohua Xie, Bing Yu, Matthew D. Warren, Elaine A. Liu, Vishal R. Dhere, Chunyang Li, Ivan Pradilla, Mylin A. Torres, Ya Wang, William S. Dynan, Paul W. Doetsch, Xingming Deng, Nicholas T. Seyfried, David Gius, David S. Yu
Published 2016-02-01

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

by Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Published 2017-08-01