Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

by Lavinia A. Carabet, Paul S. Rennie, Artem Cherkasov
Published 2018-12-01

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

by Paul S. Rennie, Artem Cherkasov, Nada Lallous, Kush Dalal
Published 2013-06-01

Computer-Aided Ligand Discovery for Estrogen Receptor Alpha

by Divya Bafna, Fuqiang Ban, Paul S. Rennie, Kriti Singh, Artem Cherkasov
Published 2020-06-01

To Die or to Survive, a Fatal Question for the Destiny of Prostate Cancer Cells after Androgen Deprivation Therapy

by Paul S. Rennie, Jessica Firus, William Jia, Brenda Prieur, Kai-Xin Zhang
Published 2011-03-01

Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

by Evgenia Dueva, Kriti Singh, Anastasia Kalyta, Eric LeBlanc, Paul S. Rennie, Artem Cherkasov
Published 2018-11-01

Efficacy and safety of second-line agents for treatment of metastatic castration-resistant prostate cancer progressing after docetaxel. A systematic review and meta-analysis

by Gianpaolo Perletti, Elena Monti, Emanuela Marras, Anne Cleves, Vittorio Magri, Alberto Trinchieri, Paul S. Rennie
Published 2015-07-01

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

by Lavinia A. Carabet, Eric Leblanc, Nada Lallous, Helene Morin, Fariba Ghaidi, Joseph Lee, Paul S. Rennie, Artem Cherkasov
Published 2019-02-01

Development of Novel Inhibitors Targeting the D-Box of the DNA Binding Domain of Androgen Receptor

by Mariia Radaeva, Fuqiang Ban, Fan Zhang, Eric LeBlanc, Nada Lallous, Paul S. Rennie, Martin E. Gleave, Artem Cherkasov
Published 2021-03-01

Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers

by Kriti Singh, Ravi S. N. Munuganti, Nada Lallous, Kush Dalal, Ji Soo Yoon, Aishwariya Sharma, Takeshi Yamazaki, Artem Cherkasov, Paul S. Rennie
Published 2018-02-01

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

by Stefan J. Barfeld, Alfonso Urbanucci, Harri M. Itkonen, Ladan Fazli, Jessica L. Hicks, Bernd Thiede, Paul S. Rennie, Srinivasan Yegnasubramanian, Angelo M. DeMarzo, Ian G. Mills
Published 2017-04-01

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

by Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu, Turid Frahnow, Lukas Simon, Stephanie Greene, Qingping Zeng, Ladan Fazli, Paul S. Rennie, Ian G. Mills, Håvard Danielsen, Fabian Theis, John B. Patterson, Yang Jin, Fahri Saatcioglu
Published 2019-01-01

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

by Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Published 2016-01-01

Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer

by Fuqiang Ban, Eric Leblanc, Ayse Derya Cavga, Chia-Chi Flora Huang, Mark R. Flory, Fan Zhang, Matthew E. K. Chang, Hélène Morin, Nada Lallous, Kriti Singh, Martin E. Gleave, Hisham Mohammed, Paul S. Rennie, Nathan A. Lack, Artem Cherkasov
Published 2021-07-01

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

by Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Published 2017-08-01