Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

by Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette
Published 2021-04-01

Diverse virulent pneumophages infect Streptococcus mitis.

by Siham Ouennane, Philippe Leprohon, Sylvain Moineau
Published 2015-01-01

Generation of Leishmania hybrids by whole genomic DNA transformation.

by Adriano C Coelho, Philippe Leprohon, Marc Ouellette
Published 2012-01-01

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance [version 1; referees: 5 approved]

by Marie-Claude N. Laffitte, Philippe Leprohon, Barbara Papadopoulou, Marc Ouellette
Published 2016-09-01

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria

by Jessica Y. El Khoury, Alexandra Maure, Hélène Gingras, Philippe Leprohon, Marc Ouellette
Published 2019-11-01

Drug resistance analysis by next generation sequencing in Leishmania

by Philippe Leprohon, Christopher Fernandez-Prada, Élodie Gazanion, Rubens Monte-Neto, Marc Ouellette
Published 2015-04-01

MRPA-independent mechanisms of antimony resistance in Leishmania infantum

by Noélie Douanne, Victoria Wagner, Gaetan Roy, Philippe Leprohon, Marc Ouellette, Christopher Fernandez-Prada
Published 2020-08-01

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

by Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette
Published 2019-10-01

Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing.

by Adriano C Coelho, Sébastien Boisvert, Angana Mukherjee, Philippe Leprohon, Jacques Corbeil, Marc Ouellette
Published 2012-01-01

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.

by Jean-François Ritt, Frédéric Raymond, Philippe Leprohon, Danielle Légaré, Jacques Corbeil, Marc Ouellette
Published 2013-11-01

Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites

by Magali Van den Kerkhof, Yann G.-J. Sterckx, Philippe Leprohon, Louis Maes, Guy Caljon
Published 2020-06-01

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.

by Marie-Claude N Laffitte, Philippe Leprohon, Maripier Hainse, Danielle Légaré, Jean-Yves Masson, Marc Ouellette
Published 2016-06-01

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms

by Christopher Fernandez-Prada, Mansi Sharma, Marie Plourde, Eva Bresson, Gaétan Roy, Philippe Leprohon, Marc Ouellette
Published 2018-08-01

Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

by Rubens Monte-Neto, Marie-Claude N Laffitte, Philippe Leprohon, Priscila Reis, Frédéric Frézard, Marc Ouellette
Published 2015-02-01

Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant.

by Marie-Christine Brotherton, Sylvie Bourassa, Philippe Leprohon, Danielle Légaré, Guy G Poirier, Arnaud Droit, Marc Ouellette
Published 2013-01-01

New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing

by Arijit Bhattacharya, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Adriano Coelho, Philippe Leprohon, Barbara Papadopoulou, Marc Ouellette
Published 2020-01-01

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

by Chloé Rosa-Teijeiro, Victoria Wagner, Audrey Corbeil, Ilda d’Annessa, Philippe Leprohon, Rubens L. do Monte-Neto, Christopher Fernandez-Prada
Published 2021-08-01

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

by Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette
Published 2019-12-01

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

by Christopher Fernandez-Prada, Isabel M Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K Smith, Marc Ouellette
Published 2016-12-01

Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania.

by Jean-Michel Ubeda, Frédéric Raymond, Angana Mukherjee, Marie Plourde, Hélène Gingras, Gaétan Roy, Andréanne Lapointe, Philippe Leprohon, Barbara Papadopoulou, Jacques Corbeil, Marc Ouellette
Published 2014-05-01