Early life immunity in the era of systems biology: understanding development and disease

by Steven Schaffert, Purvesh Khatri
Published 2018-11-01

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures.

by Hayley Warsinske, Rohit Vashisht, Purvesh Khatri
Published 2019-04-01

Ten years of pathway analysis: current approaches and outstanding challenges.

by Purvesh Khatri, Marina Sirota, Atul J Butte
Published 2012-01-01

KLRD1-expressing natural killer cells predict influenza susceptibility

by Erika Bongen, Francesco Vallania, Paul J. Utz, Purvesh Khatri
Published 2018-06-01

Multicohort Analysis Identifies Monocyte Gene Signatures to Accurately Monitor Subset-Specific Changes in Human Diseases

by Francesco Vallania, Francesco Vallania, Liron Zisman, Liron Zisman, Liron Zisman, Claudia Macaubas, Shu-Chen Hung, Narendiran Rajasekaran, Sonia Mason, Jonathan Graf, Mary Nakamura, Elizabeth D. Mellins, Purvesh Khatri, Purvesh Khatri
Published 2021-05-01

Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection

by Erika Bongen, Haley Lucian, Avani Khatri, Gabriela K. Fragiadakis, Zachary B. Bjornson, Garry P. Nolan, Paul J. Utz, Purvesh Khatri
Published 2019-11-01

Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases

by Francesco Vallania, Andrew Tam, Shane Lofgren, Steven Schaffert, Tej D. Azad, Erika Bongen, Winston Haynes, Meia Alsup, Michael Alonso, Mark Davis, Edgar Engleman, Purvesh Khatri
Published 2018-11-01

Unique transcriptomic response to sepsis is observed among patients of different age groups.

by Steven L Raymond, María Cecilia López, Henry V Baker, Shawn D Larson, Philip A Efron, Timothy E Sweeney, Purvesh Khatri, Lyle L Moldawer, James L Wynn
Published 2017-01-01

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations

by Aurelie Tomczak, Jonathan M. Mortensen, Rainer Winnenburg, Charles Liu, Dominique T. Alessi, Varsha Swamy, Francesco Vallania, Shane Lofgren, Winston Haynes, Nigam H. Shah, Mark A. Musen, Purvesh Khatri
Published 2018-03-01

A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac DiseaseSummary

by Mitchell E. Garber, Alok Saldanha, Joel S. Parker, Wendell D. Jones, Katri Kaukinen, Kaija Laurila, Marja-Leena Lähdeaho, Purvesh Khatri, Chaitan Khosla, Daniel C. Adelman, Markku Mäki
Published 2017-07-01

Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit

by Andrew R. Moore, Jonasel Roque, Brian T. Shaller, Tola Asuni, Melissa Remmel, David Rawling, Oliver Liesenfeld, Purvesh Khatri, Jennifer G. Wilson, Joseph E. Levitt, Timothy E. Sweeney, Angela J. Rogers
Published 2021-06-01

A novel blood-based assay for treatment monitoring of tuberculosis

by Alexandra J. Zimmer, Samuel G. Schumacher, Erik Södersten, Anna Mantsoki, Romain Wyss, David H. Persing, Sara Banderby, Linda Strömqvist Meuzelaar, Jacqueline Prieto, Devasena Gnanashanmugam, Purvesh Khatri, Stefano Ongarello, Morten Ruhwald, Claudia M. Denkinger
Published 2021-06-01

High-throughput quantitative histology in systemic sclerosis skin disease using computer vision

by Chase Correia, Seamus Mawe, Shane Lofgren, Roberta G. Marangoni, Jungwha Lee, Rana Saber, Kathleen Aren, Michelle Cheng, Shannon Teaw, Aileen Hoffmann, Isaac Goldberg, Shawn E. Cowper, Purvesh Khatri, Monique Hinchcliff, J. Matthew Mahoney
Published 2020-03-01

A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections

by Michael B. Mayhew, Ljubomir Buturovic, Roland Luethy, Uros Midic, Andrew R. Moore, Jonasel A. Roque, Brian D. Shaller, Tola Asuni, David Rawling, Melissa Remmel, Kirindi Choi, James Wacker, Purvesh Khatri, Angela J. Rogers, Timothy E. Sweeney
Published 2020-03-01

A 20-Gene Set Predictive of Progression to Severe Dengue

by Makeda Robinson, Timothy E. Sweeney, Rina Barouch-Bentov, Malaya Kumar Sahoo, Larry Kalesinskas, Francesco Vallania, Ana Maria Sanz, Eliana Ortiz-Lasso, Ludwig Luis Albornoz, Fernando Rosso, Jose G. Montoya, Benjamin A. Pinsky, Purvesh Khatri, Shirit Einav
Published 2019-01-01

Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections

by Simone A. Thair, Yudong D. He, Yehudit Hasin-Brumshtein, Suraj Sakaram, Rushika Pandya, Jiaying Toh, David Rawling, Melissa Remmel, Sabrina Coyle, George N. Dalekos, Ioannis Koutsodimitropoulos, Glykeria Vlachogianni, Eleni Gkeka, Eleni Karakike, Georgia Damoraki, Nikolaos Antonakos, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, Timothy E. Sweeney
Published 2021-01-01

SIMON: Open-Source Knowledge Discovery Platform

by Adriana Tomic, Ivan Tomic, Levi Waldron, Ludwig Geistlinger, Max Kuhn, Rachel L. Spreng, Lindsay C. Dahora, Kelly E. Seaton, Georgia Tomaras, Jennifer Hill, Niharika A. Duggal, Ross D. Pollock, Norman R. Lazarus, Stephen D.R. Harridge, Janet M. Lord, Purvesh Khatri, Andrew J. Pollard, Mark M. Davis
Published 2021-01-01

Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study

by Flora Martinez Figueira Moreira, Renu Verma, Paulo Cesar Pereira dos Santos, Alessandra Leite, Andrea da Silva Santos, Rafaele Carla Pivetta de Araujo, Bruna Oliveira da Silva, Júlio Henrique Ferreira de Sá Queiroz, David H. Persing, Erik Södersten, Devasena Gnanashanmugam, Purvesh Khatri, Julio Croda, Jason R. Andrews
Published 2021-03-01

Pregnancy-Induced Alterations in NK Cell Phenotype and Function

by Mathieu Le Gars, Mathieu Le Gars, Christof Seiler, Alexander W. Kay, Nicholas L. Bayless, Elina Starosvetsky, Lindsay Moore, Shai S. Shen-Orr, Natali Aziz, Purvesh Khatri, Cornelia L. Dekker, Gary E. Swan, Mark M. Davis, Mark M. Davis, Susan Holmes, Catherine A. Blish, Catherine A. Blish, Catherine A. Blish
Published 2019-10-01

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

by Adrian Vallejo, Naiara Perurena, Elisabet Guruceaga, Pawel K. Mazur, Susana Martinez-Canarias, Carolina Zandueta, Karmele Valencia, Andrea Arricibita, Dana Gwinn, Leanne C. Sayles, Chen-Hua Chuang, Laura Guembe, Peter Bailey, David K. Chang, Andrew Biankin, Mariano Ponz-Sarvise, Jesper B. Andersen, Purvesh Khatri, Aline Bozec, E. Alejandro Sweet-Cordero, Julien Sage, Fernando Lecanda, Silve Vicent
Published 2017-02-01