CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review

by Linn Amanda Syding, Petr Nickl, Petr Kasparek, Radislav Sedlacek
Published 2020-04-01

Generation of mRx-Cre transgenic mouse line for efficient conditional gene deletion in early retinal progenitors.

by Lucie Klimova, Jitka Lachova, Ondrej Machon, Radislav Sedlacek, Zbynek Kozmik
Published 2013-01-01

Heterozygous <i>Nme7</i> Mutation Affects Glucose Tolerance in Male Rats

by Lucie Šedová, Jan Prochazka, Dagmar Zudová, Běla Bendlová, Josef Včelák, Radislav Sedlacek, Ondřej Šeda
Published 2021-07-01

ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis

by Olga Zbodakova, Karel Chalupsky, Lenka Sarnova, Petr Kasparek, Marketa Jirouskova, Martin Gregor, Radislav Sedlacek
Published 2021-06-01

CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation

by Tomas Lidak, Nikol Baloghova, Vladimir Korinek, Radislav Sedlacek, Jana Balounova, Petr Kasparek, Lukas Cermak
Published 2021-05-01

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate

by Ivana Bukova, Katarzyna Izabela Szczerkowska, Michaela Prochazkova, Inken M. Beck, Inken M. Beck, Jan Prochazka, Radislav Sedlacek
Published 2021-06-01

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1

by Matej Fabisik, Matej Fabisik, Jolana Tureckova, Jolana Tureckova, Nataliia Pavliuchenko, Nataliia Pavliuchenko, Jarmila Kralova, Jana Balounova, Kristina Vicikova, Tereza Skopcova, Frantisek Spoutil, Jana Pokorna, Pavla Angelisova, Bernard Malissen, Jan Prochazka, Jan Prochazka, Radislav Sedlacek, Radislav Sedlacek, Tomas Brdicka
Published 2021-04-01

Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis.

by Marketa Jirouskova, Olga Zbodakova, Martin Gregor, Karel Chalupsky, Lenka Sarnova, Marian Hajduch, Jiri Ehrmann, Marie Jirkovska, Radislav Sedlacek
Published 2012-01-01

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness

by Shohag Bhargava, Brian Cox, Christiana Polydorou, Veronika Gresakova, Vladimir Korinek, Hynek Strnad, Radislav Sedlacek, Trevor Allan Epp, Kallayanee Chawengsaksophak
Published 2017-08-01

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner

by Anke Seifert, Justyna Wozniak, Stefan Düsterhöft, Petr Kasparek, Radislav Sedlacek, Stephan Dreschers, Thorsten W. Orlikowsky, Daniela Yildiz, Andreas Ludwig
Published 2020-08-01

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.

by Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M Beck, Radislav Sedlacek
Published 2017-01-01

MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses.

by Inken M Beck, René Rückert, Katja Brandt, Markus S Mueller, Thorsten Sadowski, Rena Brauer, Peter Schirmacher, Rolf Mentlein, Radislav Sedlacek
Published 2008-01-01

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

by Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek
Published 2019-08-01

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.

by Jan Bayram, Ivana Malcova, Larisa Sinkovec, Jana Holubova, Gaia Streparola, David Jurnecka, Jan Kucera, Radislav Sedlacek, Peter Sebo, Jana Kamanova
Published 2020-08-01

The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach

by Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska
Published 2019-01-01

Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the <i>Nme7</i> Gene

by Lucie Šedová, Ivana Buková, Pavla Bažantová, Silvia Petrezsélyová, Jan Prochazka, Elena Školníková, Dagmar Zudová, Josef Včelák, Pavol Makovický, Běla Bendlová, Ondřej Šeda, Radislav Sedlacek
Published 2021-04-01

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice

by Romana Mikyskova, Marie Indrova, Ivan Stepanek, Ivan Kanchev, Jana Bieblova, Sarka Vosahlikova, Irena Moserova, Iva Truxova, Jitka Fucikova, Jirina Bartunkova, Radek Spisek, Radislav Sedlacek, Milan Reinis
Published 2017-12-01

LAMP3 deficiency affects surfactant homeostasis in mice.

by Lars P Lunding, Daniel Krause, Guido Stichtenoth, Cordula Stamme, Niklas Lauterbach, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedlacek, Paul Saftig, Dominik Schwudke, Michael Wegmann, Markus Damme
Published 2021-06-01

Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors

by Jana Balounová, Iva Šplíchalová, Martina Dobešová, Michal Kolář, Karel Fišer, Jan Procházka, Radislav Sedlacek, Andrea Jurisicova, Hoon-ki Sung, Vladimír Kořínek, Meritxell Alberich-Jorda, Isabelle Godin, Dominik Filipp
Published 2019-11-01

Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

by Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Published 2020-05-01