Application of Hybrid Genetic Algorithm Routine in Optimizing Food and Bioengineering Processes

by Jaya Shankar Tumuluru, Richard McCulloch
Published 2016-11-01

Antigenic variation in Trypanosoma brucei: joining the DOTs.

by Chris Stockdale, Michal R Swiderski, J David Barry, Richard McCulloch
Published 2008-07-01

Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.

by Emma Briggs, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Richard McCulloch
Published 2018-12-01

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

by Emma M. Briggs, Federico Rojas, Richard McCulloch, Keith R. Matthews, Thomas D. Otto
Published 2021-09-01

Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes

by Anna Nenarokova, Kristína Záhonová, Marija Krasilnikova, Ondřej Gahura, Richard McCulloch, Alena Zíková, Vyacheslav Yurchenko, Julius Lukeš
Published 2019-07-01

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.

by Marcelo Santos da Silva, Galadriel A Hovel-Miner, Emma M Briggs, Maria Carolina Elias, Richard McCulloch
Published 2018-11-01

Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture.

by Calvin Tiengwe, Lucio Marcello, Helen Farr, Catarina Gadelha, Richard Burchmore, J David Barry, Stephen D Bell, Richard McCulloch
Published 2012-01-01

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

by Jeziel Dener Damasceno, Catarina A Marques, Dario Beraldi, Kathryn Crouch, Craig Lapsley, Ricardo Obonaga, Luiz RO Tosi, Richard McCulloch
Published 2020-09-01

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

by Fernando Fernandez-Cortes, Tiago D. Serafim, Jonathan M. Wilkes, Nathaniel G. Jones, Ryan Ritchie, Richard McCulloch, Jeremy C. Mottram
Published 2017-07-01

Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids

by Gabriel L. A. Silva, Gabriel L. A. Silva, Luiz R. O. Tosi, Richard McCulloch, Jennifer Ann Black, Jennifer Ann Black
Published 2021-08-01

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication.

by Jeziel D Damasceno, João Reis-Cunha, Kathryn Crouch, Dario Beraldi, Craig Lapsley, Luiz R O Tosi, Daniella Bartholomeu, Richard McCulloch
Published 2020-07-01

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

by Jennifer Ann Black, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Nicholas Dickens, Luiz R.O. Tosi, Jeremy C. Mottram, Richard McCulloch
Published 2020-01-01

Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress

by Viviane Grazielle-Silva, Viviane Grazielle-Silva, Tehseen Fatima Zeb, Richard Burchmore, Carlos Renato Machado, Richard McCulloch, Santuza M. R. Teixeira
Published 2020-04-01

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

by Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens, Richard McCulloch
Published 2016-05-01

Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei

by Calvin Tiengwe, Lucio Marcello, Helen Farr, Nicholas Dickens, Steven Kelly, Michal Swiderski, Diane Vaughan, Keith Gull, J. David Barry, Stephen D. Bell, Richard McCulloch
Published 2012-07-01

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.

by Jennifer A Stortz, Tiago D Serafim, Sam Alsford, Jonathan Wilkes, Fernando Fernandez-Cortes, Graham Hamilton, Emma Briggs, Leandro Lemgruber, David Horn, Jeremy C Mottram, Richard McCulloch
Published 2017-07-01

Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.

by Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C Campos, Julia B Miranda, Ceres L Alves, Carlos R Machado, Richard McCulloch, Santuza M R Teixeira
Published 2015-06-01

Replication origin location might contribute to genetic variability in Trypanosoma cruzi

by Christiane Bezerra de Araujo, Julia Pinheiro Chagas da Cunha, Davi Toshio Inada, Jeziel Damasceno, Alex Ranieri Jerônimo Lima, Priscila Hiraiwa, Catarina Marques, Evonnildo Gonçalves, Milton Yutaka Nishiyama-Junior, Richard McCulloch, Maria Carolina Elias
Published 2020-06-01

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.

by Siddharth Jayaraman, Claire Harris, Edith Paxton, Anne-Marie Donachie, Heli Vaikkinen, Richard McCulloch, James P J Hall, John Kenny, Luca Lenzi, Christiane Hertz-Fowler, Christina Cobbold, Richard Reeve, Tom Michoel, Liam J Morrison
Published 2019-04-01

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

by Sylvain Biéler, Harald Waltenberger, Michael P Barrett, Richard McCulloch, Jeremy C Mottram, Mark Carrington, Wilhelm Schwaeble, James McKerrow, Margaret A Phillips, Paul A Michels, Philippe Büscher, Jean-Charles Sanchez, Richard Bishop, Derrick R Robinson, James Bangs, Michael Ferguson, Barbara Nerima, Audrey Albertini, Gerd Michel, Magdalena Radwandska, Joseph Mathu Ndung'u
Published 2016-01-01