Divergent mutational processes distinguish hypoxic and normoxic tumours

by Vinayak Bhandari, Constance H. Li, Robert G. Bristow, Paul C. Boutros, PCAWG Consortium
Published 2020-02-01

Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer

by Alan eDal Pra, Jennifer eLocke, Gerben eBorst, Stéphane eSupiot, Robert G Bristow
Published 2016-02-01

Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.

by Ines Lohse, Ramya Kumareswaran, Pinjiang Cao, Bethany Pitcher, Steven Gallinger, Robert G Bristow, David W Hedley
Published 2016-01-01

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

by Qian Tan, Marina Wang, Man Yu, Junyan Zhang, Robert G Bristow, Richard P Hill, Ian F Tannock
Published 2016-06-01

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

by Chantal H M A Ramaekers, Twan van den Beucken, Robert G Bristow, Roland K Chiu, Daniel Durocher, Bradly G Wouters
Published 2014-01-01

Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

by Qi Wang, Kangping Cui, Osvaldo Espin-Garcia, Dangxiao Cheng, Xiaoping Qiu, Zhuo Chen, Malcolm Moore, Robert G Bristow, Wei Xu, Sandy Der, Geoffrey Liu
Published 2013-01-01

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

by Stefania Berton, Martina Cusan, Ilenia Segatto, Francesca Citron, Sara D’Andrea, Sara Benevol, Michele Avanzo, Alessandra Dall’Acqua, Monica Schiappacassi, Robert G. Bristow, Barbara Belletti, Gustavo Baldassarre
Published 2017-04-01

Use of Sequenom sample ID Plus® SNP genotyping in identification of FFPE tumor samples.

by Jessica K Miller, Nicholas Buchner, Lee Timms, Shirley Tam, Xuemei Luo, Andrew M K Brown, Danielle Pasternack, Robert G Bristow, Michael Fraser, Paul C Boutros, John D McPherson
Published 2014-01-01

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

by Becky A. S. Bibby, Niluja Thiruthaneeswaran, Lingjian Yang, Ronnie R. Pereira, Elisabet More, Darragh G. McArt, Paul O’Reilly, Robert G. Bristow, Kaye J. Williams, Ananya Choudhury, Catharine M. L. West
Published 2021-07-01

MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

by Sanjana Chowdhury, Eric Yung, Melania Pintilie, Hala Muaddi, Selim Chaib, ManTek Yeung, Manlio Fusciello, Jenna Sykes, Bethany Pitcher, Anna Hagenkort, Trevor McKee, Ravi Vellanki, Eric Chen, Robert G Bristow, Bradly G Wouters, Marianne Koritzinsky
Published 2016-01-01

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

by René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster, Geert J. L. H. van Leenders
Published 2018-01-01

Valection: design optimization for validation and verification studies

by Christopher I Cooper, Delia Yao, Dorota H Sendorek, Takafumi N Yamaguchi, Christine P’ng, Kathleen E Houlahan, Cristian Caloian, Michael Fraser, SMC-DNA Challenge Participants, Kyle Ellrott, Adam A Margolin, Robert G Bristow, Joshua M Stuart, Paul C Boutros
Published 2018-09-01

The Terry Fox Research Institute Canadian Prostate Cancer Biomarker Network: an analysis of a pan-Canadian multi-center cohort for biomarker validation

by Véronique Ouellet, Armen Aprikian, Alain Bergeron, Fadi Brimo, Robert G. Bristow, Simone Chevalier, Darrel Drachenberg, Ladan Fazli, Neil E. Fleshner, Martin Gleave, Pierre Karakiewicz, Laurence Klotz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Jeremy A. Squire, Mathieu Latour, Dominique Trudel, Anne-Marie Mes-Masson, Fred Saad
Published 2018-09-01

Mitochondrial mutations drive prostate cancer aggression

by Julia F. Hopkins, Veronica Y. Sabelnykova, Joachim Weischenfeldt, Ronald Simon, Jennifer A. Aguiar, Rached Alkallas, Lawrence E. Heisler, Junyan Zhang, John D. Watson, Melvin L. K. Chua, Michael Fraser, Francesco Favero, Chris Lawerenz, Christoph Plass, Guido Sauter, John D. McPherson, Theodorus van der Kwast, Jan Korbel, Thorsten Schlomm, Robert G. Bristow, Paul C. Boutros
Published 2017-09-01

Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers.

by Lorin Dodbiba, Jennifer Teichman, Andrew Fleet, Henry Thai, Maud H W Starmans, Roya Navab, Zhuo Chen, Hala Girgis, Lawson Eng, Osvaldo Espin-Garcia, Xiaowei Shen, Bizhan Bandarchi, Joerg Schwock, Ming-Sound Tsao, Hala El-Zimaity, Sandy D Der, Wei Xu, Robert G Bristow, Gail E Darling, Paul C Boutros, Laurie E Ailles, Geoffrey Liu
Published 2015-01-01

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

by Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien
Published 2020-01-01

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

by Renea A. Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G. Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N. Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E. Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G. Lawrence, Lee Timms, Declan G. Murphy, Mark Frydenberg, Julia F. Hopkins, Damien Bolton, David Clouston, John D. McPherson, Theodorus van der Kwast, Paul C. Boutros, Gail P. Risbridger, Robert G. Bristow
Published 2017-01-01

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer

by Lingjian Yang, Darren Roberts, Mandeep Takhar, Nicholas Erho, Becky A.S. Bibby, Niluja Thiruthaneeswaran, Vinayak Bhandari, Wei-Chen Cheng, Syed Haider, Amy M.B. McCorry, Darragh McArt, Suneil Jain, Mohammed Alshalalfa, Ashley Ross, Edward Schaffer, Robert B. Den, R. Jeffrey Karnes, Eric Klein, Peter J. Hoskin, Stephen J. Freedland, Alastair D. Lamb, David E. Neal, Francesca M. Buffa, Robert G. Bristow, Paul C. Boutros, Elai Davicioni, Ananya Choudhury, Catharine M.L. West
Published 2018-05-01

ONECUT2 is a driver of neuroendocrine prostate cancer

by Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He
Published 2019-01-01