A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

by Praveen K Vayalil, Joo-Yeun Oh, Fen Zhou, Anne R Diers, M Ryan Smith, Hafez Golzarian, Patsy G Oliver, Robin A J Smith, Michael P Murphy, Sadanandan E Velu, Aimee Landar
Published 2015-01-01

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

by Rida Mourtada, Sonali B Fonseca, Simon P Wisnovsky, Mark P Pereira, Xiaoming Wang, Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin A J Smith, Michael P Murphy, Aaron D Schimmer, Shana O Kelley
Published 2013-01-01

Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

by M. Ryan Smith, Praveen K. Vayalil, Fen Zhou, Gloria A. Benavides, Reena R. Beggs, Hafez Golzarian, Bhavitavya Nijampatnam, Patsy G. Oliver, Robin A.J. Smith, Michael P. Murphy, Sadanandan E. Velu, Aimee Landar
Published 2016-08-01