Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data

by Tasha Nagamine, Brian Gillette, Alexey Pakhomov, John Kahoun, Hannah Mayer, Rolf Burghaus, Jörg Lippert, Mayur Saxena
Published 2020-12-01

A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interact...

by Sebastian Frechen, Juri Solodenko, Thomas Wendl, André Dallmann, Ibrahim Ince, Thorsten Lehr, Jörg Lippert, Rolf Burghaus
Published 2021-06-01

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

by Rolf Burghaus, Katrin Coboeken, Thomas Gaub, Lars Kuepfer, Anke Sensse, Hans-Ulrich Siegmund, Wolfgang Weiss, Wolfgang Mueck, Joerg Lippert
Published 2011-01-01

Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study

by Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Matthias Frede, Katrin Coboeken, Jan Stampfuss, Rolf Burghaus, Wolfgang Mück, Jörg Lippert
Published 2018-12-01

Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

by Rebekka Fendt, Ute Hofmann, Annika R. P. Schneider, Elke Schaeffeler, Rolf Burghaus, Ali Yilmaz, Lars Mathias Blank, Reinhold Kerb, Jörg Lippert, Jan‐Frederik Schlender, Matthias Schwab, Lars Kuepfer
Published 2021-07-01

Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

by Jörg Lippert, Rolf Burghaus, Andrea Edginton, Sebastian Frechen, Mats Karlsson, Andreas Kovar, Thorsten Lehr, Peter Milligan, Valerie Nock, Sergej Ramusovic, Matthew Riggs, Stephan Schaller, Jan Schlender, Stephan Schmidt, Michaël Sevestre, Erik Sjögren, Juri Solodenko, Alexander Staab, Donato Teutonico
Published 2019-12-01

Algorithmic surveillance of ICU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy

by Stefan Kluge, Christian Putensen, Danny Ammon, Silke Haferkamp, Saskia Deffge, Thomas Wendt, Daniel Tiller, André Scherag, Philipp Simon, Johannes Bickenbach, Sebastian Johannes Fritsch, Julian Benedict Kunze, Oliver Maassen, Jennifer Kistermann, Irina Lutz, Nora Kristiana Voellm, Volker Lowitsch, Richard Polzin, Konstantin Sharafutdinov, Hannah Mayer, Lars Kuepfer, Rolf Burghaus, Walter Schmitt, Joerg Lippert, Morris Riedel, Chadi Barakat, André Stollenwerk, Simon Fonck, Sven Zenker, Felix Erdfelder, Daniel Grigutsch, Rainer Kram, Susanne Beyer, Knut Kampe, Jan Erik Gewehr, Friederike Salman, Patrick Juers, Emilia Wisotzki, Sebastian Gross, Lorenz Homeister, Frank Bloos, Susanne Mueller, Julia Palm, Nora Jahn, Markus Loeffler, Tobias Schuerholz, Petra Groeber, Andreas Schuppert
Published 2021-04-01