Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders

by Ronald W. Irwin, Christine M. Solinsky, Roberta Diaz Brinton
Published 2014-07-01

Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease

by Ronald W. Irwin, Jun Ming Wang, Shuhua eChen, Roberta Diaz Brinton
Published 2012-01-01

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.

by Shuhua Chen, Jun Ming Wang, Ronald W Irwin, Jia Yao, Lifei Liu, Roberta Diaz Brinton
Published 2011-01-01

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.

by Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton
Published 2015-01-01

A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats.

by Jun Ming Wang, Xu Hou, Samuel Adeosun, Rosanne Hill, Sherry Henry, Ian Paul, Ronald W Irwin, Xiao-Ming Ou, Steven Bigler, Craig Stockmeier, Roberta Diaz Brinton, Elise Gomez-Sanchez
Published 2012-01-01