Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

by Rosa M. Reguera, Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Rafael Balaña-Fouce
Published 2014-12-01

Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.

by Rosario Díaz González, Yolanda Pérez Pertejo, David Ordóñez, Rafael Balaña-Fouce, Rosa M Reguera
Published 2007-01-01

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

by Rafael Balaña-Fouce, Raquel Álvarez-Velilla, Christopher Fernández-Prada, Carlos García-Estrada, Rosa M. Reguera
Published 2014-12-01

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

by Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce
Published 2013-09-01

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

by Christopher F Prada, Raquel Álvarez-Velilla, Rosario Díaz-Gozález, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2013-01-01

Correction: First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones.

by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2016-05-01

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones.

by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2014-09-01

Antiparasitic effect of synthetic aromathecins on Leishmania infantum

by Rosa M. Reguera, Raquel Álvarez-Velilla, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, Mark Cushman, Yolanda Pérez-Pertejo
Published 2019-11-01

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

by Camino Gutiérrez-Corbo, Raquel Álvarez-Velilla, Rosa M. Reguera, Carlos García-Estrada, Mark Cushman, Rafael Balaña-Fouce, Yolanda Pérez-Pertejo
Published 2019-12-01

Reproduction in Trypanosomatids: Past and Present

by Camino Gutiérrez-Corbo, Bárbara Domínguez-Asenjo, María Martínez-Valladares, Yolanda Pérez-Pertejo, Carlos García-Estrada, Rafael Balaña-Fouce, Rosa M. Reguera
Published 2021-05-01

Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)

by Asier Selas, María Fuertes, Estela Melcón-Fernández, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Francisco Palacios, Concepcion Alonso
Published 2021-08-01

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB

by Yolanda Pérez-Pertejo, José M. Escudero-Martínez, Rosa M. Reguera, Rafael Balaña-Fouce, Pablo A. García, Pablo G. Jambrina, Arturo San Feliciano, María-Ángeles Castro
Published 2019-12-01

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis.

by Estefanía Calvo-Álvarez, Kostantinos Stamatakis, Carmen Punzón, Raquel Álvarez-Velilla, Ana Tejería, José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Manuel Fresno, Rafael Balaña-Fouce, Rosa M Reguera
Published 2015-03-01

Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3

by Manuel Soto, Laura Ramírez, José Carlos Solana, Emma C. L. Cook, Elena Hernández-García, Sara Charro-Zanca, Ana Redondo-Urzainqui, Rosa M. Reguera, Rafael Balaña-Fouce, Salvador Iborra
Published 2020-12-01

Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria

by María Álvarez-Bardón, Yolanda Pérez-Pertejo, César Ordóñez, Daniel Sepúlveda-Crespo, Nestor M. Carballeira, Babu L. Tekwani, Sankaranarayanan Murugesan, Maria Martinez-Valladares, Carlos García-Estrada, Rosa M. Reguera, Rafael Balaña-Fouce
Published 2020-03-01

Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1

by Kamilla Vandsø Petersen, Asier Selas, Kirstine Mejlstrup Hymøller, Karol Mizielinski, Maria Thorsager, Magnus Stougaard, Concepcion Alonso, Francisco Palacios, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Cinzia Tesauro
Published 2021-08-01

Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum

by José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Rosa M. Reguera, María Ángeles Castro, María Victoria Rojo, Carolina Santiago, Andrés Abad, Pablo Anselmo García, José Luis López-Pérez, Arturo San Feliciano, Rafael Balaña-Fouce
Published 2017-12-01

Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishman...

by Estefania Calvo-Álvarez, Nestor Adrian Guerrero, Raquel Alvarez-Velilla, Christopher Fernández Prada, Jose María Requena, Carmen Punzón, Miguel Ángel Llamas, Francisco J Arévalo, Luis Rivas, Manuel Fresno, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2012-01-01