A novel mutation in the leptin gene (W121X) in an Egyptian family

by Inas Mazen, Khalda Amr, Sally Tantawy, I. Sadaf Farooqi, Mona El Gammal
Published 2014-01-01

Genetic variance in the spinocerebellar ataxia type 2 (ATXN2) gene in children with severe early onset obesity.

by Karla P Figueroa, Sadaf Farooqi, Kristopher Harrup, Johnathan Frank, Stephen O'Rahilly, Stefan M Pulst
Published 2009-12-01

Oxytocin administration suppresses hypothalamic activation in response to visual food cues

by Agatha A. van der Klaauw, Hisham Ziauddeen, Julia M. Keogh, Elana Henning, Sekesai Dachi, Paul C. Fletcher, I. Sadaf Farooqi
Published 2017-06-01

Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient.

by Sabine Frank, Martin Heni, Anja Moss, Julia von Schnurbein, Sadaf Farooqi, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Martin Wabitsch
Published 2013-01-01

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.

by Audrey E Hendricks, Stephen C Billups, Hamish N C Pike, I Sadaf Farooqi, Eleftheria Zeggini, Stephanie A Santorico, Inês Barroso, Josée Dupuis
Published 2018-10-01

Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature

by Rebekah M. Ahmed, Nga Yan Tse, Yu Chen, Elana Henning, John R. Hodges, Matthew C. Kiernan, Muireann Irish, I. Sadaf Farooqi, Olivier Piguet
Published 2021-06-01

Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels

by Sumit Bhattacharyya, Jian'an Luan, Benjamin Challis, Julia Keogh, Carl Montague, John Brennand, John Morten, Sarah Lowenbeim, Suzanne Jenkins, I. Sadaf Farooqi, Nicholas J. Wareham, Stephen O'Rahilly
Published 2006-04-01

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

by Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi
Published 2016-10-01

Neural networks associated with body composition in frontotemporal dementia

by Rebekah M. Ahmed, Ramon Landin‐Romero, Cheng T. Liang, Julia M. Keogh, Elana Henning, Cherie Strikwerda‐Brown, Emma M. Devenney, John R. Hodges, Matthew C. Kiernan, I. Sadaf Farooqi, Olivier Piguet
Published 2019-09-01

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

by Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel, Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi
Published 2018-03-01

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

by Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle
Published 2018-11-01

Genetic architecture of human thinness compared to severe obesity.

by Fernando Riveros-McKay, Vanisha Mistry, Rebecca Bounds, Audrey Hendricks, Julia M Keogh, Hannah Thomas, Elana Henning, Laura J Corbin, Understanding Society Scientific Group, Stephen O'Rahilly, Eleftheria Zeggini, Eleanor Wheeler, Inês Barroso, I Sadaf Farooqi
Published 2019-01-01

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity.

by Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, I Sadaf Farooqi, Christopher J Lelliott, Steven C Munger, Stephen O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, Darren W Logan
Published 2020-09-01

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

by Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola B.F. Monteiro, Suli-Anne Laurin, Julia M. Keogh, Elana Henning, Rebecca Bounds, Carole A. Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M. Madan Babu, I. Sadaf Farooqi, Jacek Mokrosiński
Published 2021-03-01

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

by Lee Moir, Elena G. Bochukova, Rebecca Dumbell, Gareth Banks, Rasneer S. Bains, Patrick M. Nolan, Cheryl Scudamore, Michelle Simon, Kimberly A. Watson, Julia Keogh, Elana Henning, Audrey Hendricks, Stephen O'Rahilly, Inês Barroso, Adrienne E. Sullivan, David C. Bersten, Murray L. Whitelaw, Susan Kirsch, Elizabeth Bentley, I. Sadaf Farooqi, Roger D. Cox
Published 2017-11-01

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

by Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Published 2021-09-01

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

by Yongjie Yang, Agatha A. van der Klaauw, Liangru Zhu, Tessa M. Cacciottolo, Yanlin He, Lukas K. J. Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M. Keogh, Elana Henning, Matthew C. Banton, Audrey E. Hendricks, Elena G. Bochukova, Vanisha Mistry, Katherine L. Lawler, Lan Liao, Jianming Xu, Stephen O’Rahilly, Qingchun Tong, UK10K Consortium, Inês Barroso, Bert W. O’Malley, I. Sadaf Farooqi, Yong Xu
Published 2019-04-01

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

by Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg
Published 2017-10-01

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

by Maud Alligier, Romain Barrès, Ellen E. Blaak, Yves Boirie, Jildau Bouwman, Paul Brunault, Kristina Campbell, Karine Clément, I. Sadaf Farooqi, Nathalie J. Farpour-Lambert, Gema Frühbeck, Gijs H. Goossens, Jorg Hager, Jason C.G. Halford, Hans Hauner, David Jacobi, Chantal Julia, Dominique Langin, Andrea Natali, Martin Neovius, Jean Michel Oppert, Uberto Pagotto, Antonio L. Palmeira, Helen Roche, Mikael Rydén, André J. Scheen, Chantal Simon, Thorkild I.A. Sorensen, Luc Tappy, Hannele Yki-Järvinen, Olivier Ziegler, Martine Laville
Published 2020-01-01

CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1.

by Abhishek Nag, Elena G Bochukova, Barbara Kremeyer, Desmond D Campbell, Heike Muller, Ana V Valencia-Duarte, Julio Cardona, Isabel C Rivas, Sandra C Mesa, Mauricio Cuartas, Jharley Garcia, Gabriel Bedoya, William Cornejo, Luis D Herrera, Roxana Romero, Eduardo Fournier, Victor I Reus, Thomas L Lowe, I Sadaf Farooqi, Tourette Syndrome Association International Consortium for Genetics, Carol A Mathews, Lauren M McGrath, Dongmei Yu, Ed Cook, Kai Wang, Jeremiah M Scharf, David L Pauls, Nelson B Freimer, Vincent Plagnol, Andrés Ruiz-Linares
Published 2013-01-01