Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development

by Tae Hyun Park, Seung-Hyun Bae, Seoung Min Bong, Seong Eon Ryu, Hyonchol Jang, Byung Il Lee
Published 2020-10-01

Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

by Jain Ha, Sewoong Lee, Jiyoung Park, Jihye Seo, Eunjeong Kang, Haelim Yoon, Ba Reum Kim, Hyeon Kyu Lee, Seong Eon Ryu, Sayeon Cho
Published 2021-08-01

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab

by Hyun Tae Lee, Ju Yeon Lee, Heejin Lim, Sang Hyung Lee, Yu Jeong Moon, Hyo Jeong Pyo, Seong Eon Ryu, Woori Shin, Yong-Seok Heo
Published 2017-07-01

Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28.

by Bonsu Ku, Won Hong, Chae Won Keum, Myeongbin Kim, Hyunyeol Ryu, Donghwan Jeon, Ho-Chul Shin, Jae Hoon Kim, Seung Jun Kim, Seong Eon Ryu
Published 2017-01-01

Synthesis and Structure–Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research

by Minjin Yoo, Tae Hyun Park, Miyoun Yoo, Yeongrin Kim, Joo-Youn Lee, Kyu Myung Lee, Seong Eon Ryu, Byung Il Lee, Kwan-Young Jung, Chi Hoon Park
Published 2021-03-01

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

by Woori Shin, Hyun Tae Lee, Heejin Lim, Sang Hyung Lee, Ji Young Son, Jee Un Lee, Ki-Young Yoo, Seong Eon Ryu, Jaejun Rhie, Ju Yeon Lee, Yong-Seok Heo
Published 2018-03-01

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

by Ju Yeon Lee, Hyun Tae Lee, Woori Shin, Jongseok Chae, Jaemo Choi, Sung Hyun Kim, Heejin Lim, Tae Won Heo, Kyeong Young Park, Yeon Ji Lee, Seong Eon Ryu, Ji Young Son, Jee Un Lee, Yong-Seok Heo
Published 2016-10-01