Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

by Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan, Christian M. Metallo
Published 2018-10-01

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

by Pu Wang, Jing Wu, Shenghong Ma, Lei Zhang, Jun Yao, Katherine A. Hoadley, Matthew D. Wilkerson, Charles M. Perou, Kun-Liang Guan, Dan Ye, Yue Xiong
Published 2015-12-01