A Short History of the Genome-Wide Association Study: Where We Were and Where We Are Going

by Shiro Ikegawa
Published 2012-12-01

Stickler Syndrome Type 1 with Short Stature and Atypical Ocular Manifestations

by Manisha Goyal, Seema Kapoor, Shiro Ikegawa, Gen Nishimura
Published 2016-01-01

Bi-allelic loss-of-function variants in TMEM53 cause a novel type of sclerosing bone disorder in human and mouse

by Long Guo, Jingyi Xue, Zheng Wang, Shiro Ikegawa
Published 2021-04-01

Identification of SLC4A2 as a new causal gene for osteopetrosis in human

by Jingyi Xue, Zheng Wang, Long Guo, Shiro Ikegawa
Published 2021-04-01

A novel IFITM5 variant associates with phenotype of osteoporosis with calvarial doughnut lesions

by Riikka Mäkitie, Minna Pekkinen, Naoya Morisada, Daisuke Kobayashi, Yoshiro Yonezawa, Gen Nishimura, Shiro Ikegawa, Outi Mäkitie
Published 2021-04-01

Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model

by Huacheng Hou, Ke Zheng, Guanghu Wang, Shiro Ikegawa, Minghao Zheng, Xiang Gao, Jinzhong Qin, Huajian Teng, Qing Jiang
Published 2015-01-01

Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO)

by Yuka Kinoshita, Yuichi Takashi, Nobuaki Ito, Shiro Ikegawa, Hiroyuki Mano, Tetsuo Ushiku, Masashi Fukayama, Masaomi Nangaku, Seiji Fukumoto
Published 2019-06-01

CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage

by Kazuki Kodama, Hiroaki Takahashi, Nobuyasu Oiji, Kenta Nakano, Tadashi Okamura, Kimie Niimi, Eiki Takahashi, Long Guo, Shiro Ikegawa, Tatsuya Furuichi
Published 2020-06-01

Double non-contiguous fractures in a patient with spondylo-epiphyseal dysplasia with spinal ankylosis treated with open and percutaneous spinal fixation technique: a case report

by Takahiro Ushijima, Kenichi Kawaguchi, Tadashi Matsumoto, Masaki Takagi, Tatsuro Kondoh, Gen Nishimura, Aritoshi Iida, Shiro Ikegawa, Nobuhiko Haga, Go Kato
Published 2018-02-01

Molecular Classification of Knee Osteoarthritis

by Zhongyang Lv, Yannick Xiaofan Yang, Jiawei Li, Yuxiang Fei, Hu Guo, Ziying Sun, Jun Lu, Xingquan Xu, Qing Jiang, Shiro Ikegawa, Dongquan Shi
Published 2021-08-01

rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.

by Ya-Feng Wen, James Cheng-Chung Wei, Yu-Wen Hsu, Hung-Yi Chiou, Henry Sung-Ching Wong, Ruey-Hong Wong, Shiro Ikegawa, Wei-Chiao Chang
Published 2014-01-01

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

by Zhongyang Lv, Xingquan Xu, Ziying Sun, Yannick Xiaofan Yang, Hu Guo, Jiawei Li, Kuoyang Sun, Rui Wu, Jia Xu, Qing Jiang, Shiro Ikegawa, Dongquan Shi
Published 2021-05-01

Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model

by Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang, Dongquan Shi
Published 2021-07-01

FOXC2 mutations in familial and sporadic spinal extradural arachnoid cyst.

by Yoji Ogura, Shoji Yabuki, Aritoshi Iida, Ikuyo Kou, Masahiro Nakajima, Hiroki Kano, Masaaki Shiina, Shinichi Kikuchi, Yoshiaki Toyama, Kazuhiro Ogata, Masaya Nakamura, Morio Matsumoto, Shiro Ikegawa
Published 2013-01-01

Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

by James Cheng-Chung Wei, Yu-Wen Hsu, Kuo-Sheng Hung, Ruey-Hong Wong, Chun-Huang Huang, Yi-Tzu Liu, Yuh-Cherng Guo, Shiro Ikegawa, Wei-Chiao Chang
Published 2013-01-01

Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis De...

by Long Guo, Hiroshi Yamashita, Ikuyo Kou, Aki Takimoto, Makiko Meguro-Horike, Shin-ichi Horike, Tetsushi Sakuma, Shigenori Miura, Taiji Adachi, Takashi Yamamoto, Shiro Ikegawa, Yuji Hiraki, Chisa Shukunami
Published 2016-01-01

Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese.

by Ikuyo Kou, Atsushi Takahashi, Tomohiko Urano, Naoshi Fukui, Hideki Ito, Kouichi Ozaki, Toshihiro Tanaka, Takayuki Hosoi, Masataka Shiraki, Satoshi Inoue, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo, Seijiro Mori, Shiro Ikegawa
Published 2011-01-01

Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.

by Yoji Ogura, Noriko Miyake, Ikuyo Kou, Aritoshi Iida, Masahiro Nakajima, Kazuki Takeda, Shunsuke Fujibayashi, Masaaki Shiina, Eijiro Okada, Yoshiaki Toyama, Akio Iwanami, Ken Ishii, Kazuhiro Ogata, Hiroshi Asahara, Naomichi Matsumoto, Masaya Nakamura, Morio Matsumoto, Shiro Ikegawa
Published 2015-01-01

Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.

by Kei Semba, Kimi Araki, Ken-ichirou Matsumoto, Hiroko Suda, Takashi Ando, Akira Sei, Hiroshi Mizuta, Katsumasa Takagi, Mai Nakahara, Mayumi Muta, Gen Yamada, Naomi Nakagata, Aritoshi Iida, Shiro Ikegawa, Yusuke Nakamura, Masatake Araki, Kuniya Abe, Ken-ichi Yamamura
Published 2013-01-01

CELSR2 is a candidate susceptibility gene in idiopathic scoliosis.

by Elisabet Einarsdottir, Anna Grauers, Jingwen Wang, Hong Jiao, Stefan A Escher, Aina Danielsson, Ane Simony, Mikkel Andersen, Mikkel Andersen, Steen Bach Christensen, Kristina Åkesson, Ikuyo Kou, Anas M Khanshour, Acke Ohlin, Carol Wise, Shiro Ikegawa, Juha Kere, Paul Gerdhem
Published 2017-01-01