Superovulation using the combined administration of inhibin antiserum and equine chorionic gonadotropin increases the number of ovulated oocytes in C57BL/6 female mice.

by Toru Takeo, Naomi Nakagata
Published 2015-01-01

N-acetyl cysteine restores the fertility of vitrified-warmed mouse oocytes derived through ultrasuperovulation.

by Ayumi Mukunoki, Toru Takeo, Naomi Nakagata
Published 2019-01-01

Cryopreservation of mouse resources

by Toru Takeo, Satohiro Nakao, Yoshiko Nakagawa, Jorge M. Sztein, Naomi Nakagata
Published 2020-09-01

Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.

by Daisuke Matsumaru, Ryuma Haraguchi, Shinichi Miyagawa, Jun Motoyama, Naomi Nakagata, Frits Meijlink, Gen Yamada
Published 2011-01-01

The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis.

by Ryuma Haraguchi, Daisuke Matsumaru, Naomi Nakagata, Shinichi Miyagawa, Kentaro Suzuki, Sohei Kitazawa, Gen Yamada
Published 2012-01-01

Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells.

by Yoshinori Sato, Hiroshi Takata, Naoki Kobayashi, Sayaka Nagata, Naomi Nakagata, Takamasa Ueno, Masafumi Takiguchi
Published 2010-10-01

Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice

by Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Published 2017-05-01

Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice

by Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Published 2016-08-01

Tsukushi is essential for the development of the inner ear

by Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song, Ryosei Minoda
Published 2020-03-01

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2

by Koutaro Takamatsu, Tokunori Ikeda, Miwa Haruta, Keiko Matsumura, Yasuhiro Ogi, Naomi Nakagata, Makoto Uchino, Yukio Ando, Yasuharu Nishimura, Satoru Senju
Published 2014-11-01

Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

by Kentaro Suzuki, Yasuha Adachi, Tomokazu Numata, Shoko Nakada, Motoko Yanagita, Naomi Nakagata, Sylvia M Evans, Daniel Graf, Aris Economides, Ryuma Haraguchi, Anne M Moon, Gen Yamada
Published 2012-01-01

Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models

by Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Published 2014-01-01

Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis

by Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Published 2016-02-01

Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases

by Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Published 2019-06-01

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease

by Yuki Maeda, Keiichi Motoyama, Rena Nishiyama, Taishi Higashi, Risako Onodera, Hideaki Nakamura, Toru Takeo, Naomi Nakagata, Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Published 2019-05-01

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice

by Ryodai Shindo, Takaharu Katagiri, Sachiko Komazawa-Sakon, Masaki Ohmuraya, Wakami Takeda, Yoshiko Nakagawa, Naomi Nakagata, Tetsushi Sakuma, Takashi Yamamoto, Chiharu Nishiyama, Takashi Nishina, Soh Yamazaki, Hideto Kameda, Hiroyasu Nakano
Published 2020-03-01

A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.

by Yuta Seki, Yuki Miyasaka, Sari Suzuki, Kenta Wada, Shumpei P Yasuda, Kunie Matsuoka, Yasuhiro Ohshiba, Kentaro Endo, Rie Ishii, Hiroshi Shitara, Shin-Ichiro Kitajiri, Naomi Nakagata, Hirohide Takebayashi, Yoshiaki Kikkawa
Published 2017-01-01

An acute phase protein α1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action

by Hiroshi Watanabe, Rui Fujimura, Yuto Hiramoto, Ryota Murata, Kento Nishida, Jing Bi, Tadashi Imafuku, Hisakazu Komori, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Published 2021-04-01

A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein

by Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Published 2020-07-01

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–P...

by Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie
Published 2021-01-01