FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

by Yuichi Tsuchiya, Osamu Nakabayashi, Hiroyasu Nakano
Published 2015-12-01

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

by Hiroshi Ashida, Hiroyasu Nakano, Chihiro Sasakawa
Published 2013-01-01

Inferior vena cava compression and acute kidney injury

by Hiroyasu Nakano, Naohiko Imai, Yugo Shibagaki
Published 2019-01-01

Regulation of T cell differentiation by the AP-1 transcription factor JunB

by Takaharu Katagiri, Hideto Kameda, Hiroyasu Nakano, Soh Yamazaki
Published 2021-07-01

Development of novel methods that monitor necroptosis and the release of DAMPs at the single cell resolution

by Hiroyasu Nakano, Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Osamu Nakabayashi, Soh Yamazaki
Published 2019-01-01

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

by Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu
Published 2020-04-01

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

by Chieko Ishifune, Shin-Ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Doo Hyun Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano, Koji Yasutomo
Published 2019-05-01

A rare case of Epstein–Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report

by Nozomi Morita, Chiaki Okuse, Keigo Suetani, Hiroyasu Nakano, Tetsuya Hiraishi, Shinya Ishigooka, Shuzo Mori, Tsukasa Shimamura, Takeshi Asakura, Junki Koike, Fumio Itoh, Michihiro Suzuki
Published 2020-01-01

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

by Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano
Published 2021-01-01

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice

by Ryodai Shindo, Takaharu Katagiri, Sachiko Komazawa-Sakon, Masaki Ohmuraya, Wakami Takeda, Yoshiko Nakagawa, Naomi Nakagata, Tetsushi Sakuma, Takashi Yamamoto, Chiharu Nishiyama, Takashi Nishina, Soh Yamazaki, Hideto Kameda, Hiroyasu Nakano
Published 2020-03-01

Effects of CX3CL1 inhibition on murine bleomycin-induced interstitial pneumonia

by Soichi Yamada, Shion Miyoshi, Junko Nishio, Satoshi Mizutani, Zento Yamada, Natsuko Kusunoki, Hiroshi Sato, Yoshikazu Kuboi, Kana Hoshino-Negishi, Naoto Ishii, Toshio Imai, Tetsuo Mikami, Hiroyasu Nakano, Shinichi Kawai, Toshihiro Nanki
Published 2020-09-01

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

by Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-Ichiro Inoue
Published 2017-01-01

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

by Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano
Published 2019-04-01

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

by Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano
Published 2018-10-01

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

by Ryodai Shindo, Masaki Ohmuraya, Sachiko Komazawa-Sakon, Sanae Miyake, Yutaka Deguchi, Soh Yamazaki, Takashi Nishina, Takayuki Yoshimoto, Soichiro Kakuta, Masato Koike, Yasuo Uchiyama, Hiroyuki Konishi, Hiroshi Kiyama, Tetuo Mikami, Kenta Moriwaki, Kimi Araki, Hiroyasu Nakano
Published 2019-05-01

Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus

by Ryuta Shigefuku, Hideaki Takahashi, Hiroyasu Nakano, Tsunamasa Watanabe, Kotaro Matsunaga, Nobuyuki Matsumoto, Masaki Kato, Ryo Morita, Yousuke Michikawa, Tomohiro Tamura, Tetsuya Hiraishi, Nobuhiro Hattori, Yohei Noguchi, Kazunari Nakahara, Hiroki Ikeda, Toshiya Ishii, Chiaki Okuse, Shigeru Sase, Fumio Itoh, Michihiro Suzuki
Published 2016-09-01

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

by Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano
Published 2021-04-01

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

by Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Published 2020-06-01