Hyperspectral Image Clustering with Spatially-Regularized Ultrametrics

by Shukun Zhang, James M. Murphy
Published 2021-03-01

Post-translational control of RIPK3 and MLKL mediated necroptotic cell death [version 1; referees: 4 approved]

by James M. Murphy, James E. Vince
Published 2015-11-01

FAK Family Kinases in Vascular Diseases

by James M. Murphy, Kyuho Jeong, Ssang-Taek Steve Lim
Published 2020-05-01

A Quantitative Method to Measure Low Levels of ROS in Nonphagocytic Cells by Using a Chemiluminescent Imaging System

by Jun-Sub Kim, Kyuho Jeong, James M. Murphy, Yelitza A. R. Rodriguez, Ssang-Taek Steve Lim
Published 2019-01-01

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

by James M. Murphy, Yelitza A. R. Rodriguez, Kyuho Jeong, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Published 2020-06-01

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes

by Joanne M. Hildebrand, Bernice Lo, Sara Tomei, Valentina Mattei, Samuel N. Young, Cheree Fitzgibbon, James M. Murphy, Abeer Fadda
Published 2021-04-01

A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

by Martina Foglizzo, Adam J. Middleton, Abigail E. Burgess, Jennifer M. Crowther, Renwick C. J. Dobson, James M. Murphy, Catherine L. Day, Peter D. Mace
Published 2018-09-01

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.

by Timothy R Hercus, Emma F Barry, Mara Dottore, Barbara J McClure, Andrew I Webb, Angel F Lopez, Ian G Young, James M Murphy
Published 2013-01-01

Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

by Markus C. Kerr, Guillermo A. Gomez, Charles Ferguson, Maria C. Tanzer, James M. Murphy, Alpha S. Yap, Robert G. Parton, Wilhelmina M. Huston, Rohan D Teasdale
Published 2017-03-01

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

by Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Warren S. Alexander, Emma C. Josefsson
Published 2021-01-01

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

by Onisha Patel, Michael D. W. Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M. Murphy, Roger J. Daly, Isabelle S. Lucet
Published 2017-10-01

The molecular basis of JAK/STAT inhibition by SOCS1

by Nicholas P. D. Liau, Artem Laktyushin, Isabelle S. Lucet, James M. Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon
Published 2018-04-01

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

by Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Published 2013-01-01

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

by Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Published 2021-03-01

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

by Michael R. Oliver, Christopher R. Horne, Safal Shrestha, Jeremy R. Keown, Lung-Yu Liang, Samuel N. Young, Jarrod J. Sandow, Andrew I. Webb, David C. Goldstone, Isabelle S. Lucet, Natarajan Kannan, Peter Metcalf, James M. Murphy
Published 2021-02-01

PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment

by Andrew Steven Flies, Andrew Steven Flies, Alan Bruce Lyons, Lynn M Corcoran, Anthony T Papenfuss, Anthony T Papenfuss, Anthony T Papenfuss, James M Murphy, Graeme W Knowles, Greg M Woods, Greg M Woods, John Dominic Hayball, John Dominic Hayball
Published 2016-12-01

SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

by Jung-Hyun Kim, Kyuho Jeong, Jianfeng Li, James M. Murphy, Lana Vukadin, Joshua K. Stone, Alexander Richard, Johnny Tran, G. Yancey Gillespie, Erik K. Flemington, Robert W. Sobol, Ssang-Teak Steve Lim, Eun-Young Erin Ahn
Published 2021-09-01

Toward Consistent Observational Constraints in Climate Predictions and Projections

by Gabriele C. Hegerl, Andrew P. Ballinger, Ben B. B. Booth, Leonard F. Borchert, Lukas Brunner, Markus G. Donat, Francisco J. Doblas-Reyes, Glen R. Harris, Jason Lowe, Rashed Mahmood, Juliette Mignot, James M. Murphy, Didier Swingedouw, Antje Weisheimer
Published 2021-06-01

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

by Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Published 2021-05-01

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

by Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F. Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A. Breslin, Tracy A. Willson, Kelly Rogers, Graham F. Kay, Archa H. Fox, Haruhiko Koseki, Neil Brockdorff, James M. Murphy, Marnie E. Blewitt
Published 2018-11-01