Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

by Riley D. Metcalfe, Tracy L. Putoczki, Tracy L. Putoczki, Michael D. W. Griffin
Published 2020-07-01

Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78.

by Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael D W Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlett
Published 2013-01-01

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

by Onisha Patel, Michael D. W. Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M. Murphy, Roger J. Daly, Isabelle S. Lucet
Published 2017-10-01

Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana.

by Michael D W Griffin, Jagan M Billakanti, Akshita Wason, Sabrina Keller, Haydyn D T Mertens, Sarah C Atkinson, Renwick C J Dobson, Matthew A Perugini, Juliet A Gerrard, Frederick Grant Pearce
Published 2012-01-01

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

by Daouda A. K. Traore, Jessica A. Wisniewski, Sarena F. Flanigan, Paul J. Conroy, Santosh Panjikar, Yee-Foong Mok, Carmen Lao, Michael D. W. Griffin, Vicki Adams, Julian I. Rood, James C. Whisstock
Published 2018-09-01

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

by Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Published 2021-03-01

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

by Md. Alamgir Hossain, Florence Larrous, Stephen M. Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G. Lieu, Yee-Foong Mok, Michael D.W. Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Gregory W. Moseley, Paul R. Gooley
Published 2019-11-01

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

by Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael D W Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini
Published 2013-01-01

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

by Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Published 2018-06-01